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Titolo:
Spatial distribution of nutritive and nonnutritive vascular routes in perfused rat hindlimb muscle using microspheres
Autore:
Vincent, MA; Rattigan, S; Clark, MG; Bernard, SL; Glenny, RW;
Indirizzi:
Univ Tasmania, Div Biochem, Hobart, Tas 7001, Australia Univ Tasmania Hobart Tas Australia 7001 chem, Hobart, Tas 7001, Australia Univ Washington, Dept Med, Seattle, WA USA Univ Washington Seattle WA USA niv Washington, Dept Med, Seattle, WA USA Univ Washington, Dept Physiol & Biophys, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 iol & Biophys, Seattle, WA 98195 USA
Titolo Testata:
MICROVASCULAR RESEARCH
fascicolo: 1, volume: 61, anno: 2001,
pagine: 111 - 121
SICI:
0026-2862(200101)61:1<111:SDONAN>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW DISTRIBUTION; SKELETAL-MUSCLE; OXYGEN-UPTAKE; RABBIT; INHIBITION; METABOLISM; SEROTONIN; REST; DOG;
Keywords:
nutritive flow; nonnutritive flow; two circulatory systems in muscle; microsphere embolism; fluorescent microspheres; connective tissue vessels;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Clark, MG Univ Tasmania, Div Biochem, GPO Box 252-58, Hobart, Tas 7001, Australia Univ Tasmania GPO Box 252-58 Hobart Tas Australia 7001 Australia
Citazione:
M.A. Vincent et al., "Spatial distribution of nutritive and nonnutritive vascular routes in perfused rat hindlimb muscle using microspheres", MICROVASC R, 61(1), 2001, pp. 111-121

Abstract

Skeletal muscle appears to have two vascular flow routes, nutritive and nonnutritive, where the balance of flow is controlled by vasoconstrictors. Inthe present study, spatial distributions of the two flow routes in musclesof the perfused rat hindlimb were attempted using fluorescent microspheres(15 mum in diameter). Microspheres were injected during steady-state perfusion with norepinephrine (proposed recruiter of nutritive flow), serotonin (proposed recruiter of nonnutritive flow), or vehicle. The three-dimensional location of individual microspheres in representative muscles was determined using a Fluorescent Imaging CryoMicrotome. Norepinephrine and serotonineach increased perfusion pressure (P < 0.05) but stimulated and inhibited oxygen consumption (P < 0.05), respectively. The distribution of microspheres lodged in muscle was independent of the agent used. Spatial perfusion indices for norepinephrine, serotonin, and vehicle did not differ from each other. Similarly, there was no difference in these indices for a theoreticaldistribution where microspheres were deliberately positioned in muscle bundle capillaries or interfibrillar connective tissue vessels. We conclude that the nutritive and nonnutritive flow routes are distributed throughout muscle sections consistent with their locations in muscle bundle capillaries and interfibrillar connective tissue, respectively, (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:01:06