Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Hemorrheologic abnormalities in defined primary dyslipoproteinemias with both high and low atherosclerotic risks
Autore:
Otto, C; Ritter, MM; Richter, WO; Minkenberg, R; Schwandt, P;
Indirizzi:
Univ Munich, Klinikum Grosshadern, Dept Med 2, D-81377 Munich, Germany Univ Munich Munich Germany D-81377 , Dept Med 2, D-81377 Munich, Germany Rhein Westfal TH Aachen, Biometr Inst, D-5100 Aachen, Germany Rhein Westfal TH Aachen Aachen Germany D-5100 st, D-5100 Aachen, Germany
Titolo Testata:
METABOLISM-CLINICAL AND EXPERIMENTAL
fascicolo: 2, volume: 50, anno: 2001,
pagine: 166 - 170
SICI:
0026-0495(200102)50:2<166:HAIDPD>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; HIGH-DENSITY-LIPOPROTEIN; UNSTABLE ANGINA-PECTORIS; PLASMA VISCOSITY; BLOOD-VISCOSITY; FAMILIAL HYPERTRIGLYCERIDEMIA; EDINBURGH ARTERY; FIBRINOGEN; CHOLESTEROL; MEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Otto, C Univ Munich, Klinikum Grosshadern, Dept Med 2, Marchioninistr 15, D-81377 Munich, Germany Univ Munich Marchioninistr 15 Munich Germany D-81377 ich, Germany
Citazione:
C. Otto et al., "Hemorrheologic abnormalities in defined primary dyslipoproteinemias with both high and low atherosclerotic risks", METABOLISM, 50(2), 2001, pp. 166-170

Abstract

Dyslipoproteinemias are associated with hemorrheologic abnormalities (elevated fibrinogen concentration, higher viscosity of plasma and blood). Epidemiologic data suggest that not only elevated lipoprotein concentrations (eg. low-density lipoprotein [LDL] cholesterol), but also hemorrheologic abnormalities could causally be involved in the atherosclerotic process. To elucidate potential effects of hemorrheological disturbances, we investigated patients suffering from primary hyperlipoproteinemias with both low (familial hypertriglyceridemia, n = 25) and high (type III hyperlipoproteinemia. n = 21; familial hypercholesterolemia. n = 19; mixed hyperlipoproteinemia. n = 19) atherosclerotic risk, as well as healthy controls (n = 49) in a cross-sectional design. Dyslipoproteinemias were classified by lipoprotein measurements (using ultracentrifugation), family history, and apolipoprotein E phenotype. Hemorrheology was characterized by the measurement of fibrinogen concentration, viscosity of plasma and blood at different shear rates, and red cell aggregation (RCA) at stasis and low shear. Fibrinogen concentration was lower in controls (2.38 +/- 0.09 g/L) compared with familial hypercholesterolemia (3.19 +/- 0.19 g/L), to type III hyperlipoproteinemia (3.02 +/- 0.12 g/L), to familial hypertriglyceridemia (2.95 +/- 0.21 g/L) and to mixed hyperlipoproteinemia (3.01 +/- 0.12 g/L) (P < .05, respectively) without differences between dyslipoproteinemia groups. Plasma viscosity was higher in patients with type III hyperlipoproteinemia (1.42 +/- 0.03 mPas), withfamilial hypertriglyceridemia (1.47 +/- 0.04 mPas), and with mixed hyperlipoproteinemia (1.43 +/- 0.02 mPas) compared with controls (1.29 +/- 0.01 mPas) (P < .05, respectively). After including 6 lipoprotein parameters in a general linear model, plasma viscosity, blood viscosity, and RCA were higher in familial hypertriglyceridemia compared with healthy controls and familial hypercholesterolemia (P < .05, respectively). As most of the hemorrheologic abnormalities were still significant after adjusting for lipoprotein concentrations, they seem to be at least partly independent from direct lipoprotein effects. Hemorrheologic abnormalities in familial hypertriglyceridemia (low atherosclerotic risk) were at least as marked as in dyslipoproteinemias with high atherosclerotic risk, suggesting that it might be most important to determine lipoprotein concentrations and to define exactly the type of dyslipoproteinemia for estimating the individual cardiovascular risk in these patients. Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 16:30:45