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Titolo:
Inhibition by retinoids of antigen-induced IL-4 production in rat mast cell line RBL-2H3
Autore:
Hirasawa, N; Kagechika, H; Shudo, K; Ohuchi, K;
Indirizzi:
Tohoku Univ, Grad Sch Pharmaceut Sci, Lab Pathophysiol Biochem, Aoba Ku, Sendai, Miyagi 9808578, Japan Tohoku Univ Sendai Miyagi Japan 9808578 Ku, Sendai, Miyagi 9808578, Japan Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 ceut Sci, Bunkyo Ku, Tokyo 1130033, Japan
Titolo Testata:
LIFE SCIENCES
fascicolo: 11, volume: 68, anno: 2001,
pagine: 1287 - 1294
SICI:
0024-3205(20010202)68:11<1287:IBROAI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
FC-EPSILON-RI; ACID RECEPTORS; NF-AT; EXPRESSION; AP-1; GENE; INDUCTION; LEUKEMIA; THERAPY;
Keywords:
retinoid; mast cell; IL-4; cyclosporin A;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Hirasawa, N Tohoku Univ, Grad Sch Pharmaceut Sci, Lab Pathophysiol Biochem, Aoba Ku, Aoba Aramaki, Sendai, Miyagi 9808578, Japan Tohoku Univ Aoba Aramaki Sendai Miyagi Japan 9808578 78, Japan
Citazione:
N. Hirasawa et al., "Inhibition by retinoids of antigen-induced IL-4 production in rat mast cell line RBL-2H3", LIFE SCI, 68(11), 2001, pp. 1287-1294

Abstract

The retinoic acid receptor (RAR) agonists, Re80 and Am80, partially inhibited the antigen-induced IL-4 production by rat mast cell line RBL-2H3 in a concentration-dependent manner (0.1 to 1000 nM). Both Re80 and Am80 also reduced the antigen-induced increase in IL-4 mRNA levels. The RAR antagonist LE540 at 4 muM reversed Re80 (100 nM) - and Am80 (100 nM)-induced inhibition of IL-4 production. The retinoid X receptor agonist HX600 (1 muM) by itself did not affect IL-4 production, but enhanced the inhibitory effect of Re80 (10 nM) and of Am80 (10 nM). Cyclosporin A suppressed the antigen-induced IL-4 production almost completely at 0.3 muM These findings indicated that the antigen-induced IL-4 production by RBL-2H3 cells is partially inhibited by retinoids via RAR-dependent mechanisms. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:46:06