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Titolo:
Quantitative analysis of mucin and lectin in maxillary sinus fluids in patients with acute and chronic sinusitis
Autore:
Shinogi, J; Harada, T; Nonoyama, T; Kishioka, C; Sakakura, Y; Majima, Y;
Indirizzi:
Mie Univ, Sch Med, Dept Otorhinolaryngol, Tsu, Mie 5148507, Japan Mie Univ Tsu Mie Japan 5148507 Otorhinolaryngol, Tsu, Mie 5148507, Japan
Titolo Testata:
LARYNGOSCOPE
fascicolo: 2, volume: 111, anno: 2001,
pagine: 240 - 245
SICI:
0023-852X(200102)111:2<240:QAOMAL>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
NASAL SECRETIONS; CHILDREN; MUCUS;
Keywords:
maxillary sinus fluids; acute sinusitis; chronic sinusitis; mucin; Ulex europaeus agglutinin-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Harada, T Mie Univ, Sch Med, Dept Otorhinolaryngol, 2-174 Edobashi, Tsu, Mie 5148507, Japan Mie Univ 2-174 Edobashi Tsu Mie Japan 5148507 Mie 5148507, Japan
Citazione:
J. Shinogi et al., "Quantitative analysis of mucin and lectin in maxillary sinus fluids in patients with acute and chronic sinusitis", LARYNGOSCOP, 111(2), 2001, pp. 240-245

Abstract

Objectives: Sinusitis is characterized by quantitative and qualitative changes in mucus biosynthesis that contribute to sinus disease. In general, patients with acute sinusitis complain of purulent rhinorrhea, whereas those with chronic sinusitis complain of mucoid or mucopurulent rhinorrhea. Locally produced mucin largely contributes to the high viscoelasticity of mucus in sinusitis. In this study, the authors attempt to quantify the concentrations of mucin and lectin in the maxillary sinus fluids from these patients Study Design: To assess the concentrations of mucin and lectin in aspiratesof 11 acutely and 11 chronically inflamed maxillary sinuses, the concentration of mucin was measured by enzyme-linked immunosorbent assay (ELISA) andthat of lectin by sandwiched enzyme-linked lectin assay (ELLA). Results: The concentrations of mucin and lectin that were measured using monoclonal antibodies (HCS 4, HCS 14, and HCS 18) and Ulex europaeus agglutinin-1 (UEA-1) in chronic sinusitis were higher than those in acute sinusitis. The concentration of total protein in chronic sinusitis was lower than that in acute sinusitis. Each mucin and lectin versus total protein ratio in chronic sinusitis was higher than that in acute sinusitis. Conclusions: These data suggest that hypersecretion in chronic sinusitis may result from locally increased mucin production. Comprehension of this mechanism may be a strategy to prevent the viscous cycle of paranasal sinus fluids in chronic sinusitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:48:47