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Titolo:
Brain dopamine and obesity
Autore:
Wang, GJ; Volkow, ND; Logan, J; Pappas, NR; Wong, CT; Zhu, W; Netusil, N; Fowler, JS;
Indirizzi:
Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA Brookhaven Natl Lab Upton NY USA 11973 Lab, Dept Med, Upton, NY 11973 USA Brookhaven Natl Lab, Dept Chem, Upton, NY 11973 USA Brookhaven Natl Lab Upton NY USA 11973 ab, Dept Chem, Upton, NY 11973 USA SUNY Stony Brook, Dept Radiol, Stony Brook, NY 11794 USA SUNY Stony BrookStony Brook NY USA 11794 diol, Stony Brook, NY 11794 USA SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 hiat, Stony Brook, NY 11794 USA SUNY Stony Brook, Dept Appl Math & Stat, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 Stat, Stony Brook, NY 11794 USA
Titolo Testata:
LANCET
fascicolo: 9253, volume: 357, anno: 2001,
pagine: 354 - 357
SICI:
0140-6736(20010203)357:9253<354:BDAO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-BINDING CHARACTERISTICS; STRIATAL DOPAMINE; NUCLEUS-ACCUMBENS; C-11 RACLOPRIDE; COCAINE ABUSERS; IN-VIVO; REWARD; FOOD; ASSOCIATION; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Wang, GJ Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA Brookhaven Natl Lab Upton NY USA 11973 Med, Upton, NY 11973 USA
Citazione:
G.J. Wang et al., "Brain dopamine and obesity", LANCET, 357(9253), 2001, pp. 354-357

Abstract

Background The cerebral mechanisms underlying the behaviours that lead to pathological overeating and obesity are poorly understood. Dopamine, a neurotransmitter that modulates rewarding properties of food, is likely to be involved. To test the hypothesis that obese individuals have abnormalities in brain dopamine activity we measured the availability of dopamine D-2 receptors in brain. Methods Brain dopamine D-2 receptor availability was measured with positron emission tomography (PET) and [C-11]raclopride (a radioligand for the dopamine D-2 receptor). Bmax/Kd (ratio of the distribution volumes in striatumto that in cerebellum minus 1) was used as a measure of dopamine D-2 receptor availability. Brain glucose metabolism was also assessed with 2-deoxy-2[F-18]fluoro-D-glucose (FDG). Findings Striatal dopamine D-2 receptor availability was significantly lower in the ten obese individuals (2.47 [SD 0.36]) than in controls (2.99 [0.41]; p less than or equal to0.0075). In the obese individuals body mass index (BMI) correlated negatively with the measures of D-2 receptors (r=0.84; p less than or equal to0.002); the individuals with the lowest D-2 values had the largest BMI. By contrast, neither whole brain nor striatal metabolism differed between obese individuals and controls, indicating that striatalreductions in D-2 receptors were not due to a systematic reduction in radiotracer delivery. Interpretation The availability of dopamine D-2 receptor was decreased in obese individuals in proportion to their BMI. Dopamine modulates motivationand reward circuits and hence dopamine deficiency in obese individuals mayperpetuate pathological eating as a means to compensate for decreased activation of these circuits. Strategies aimed at improving dopamine function may be beneficial in the treatment of obese individuals.

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Documento generato il 22/01/20 alle ore 12:49:43