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Titolo:
Homocysteine, its metabolites, and B-group vitamins in renal transplant patients
Autore:
Stein, G; Muller, A; Busch, M; Fleck, C; Sperschneider, H;
Indirizzi:
Univ Jena, Dept Internal Med 4, Inst Pharmacol, D-07740 Jena, Germany UnivJena Jena Germany D-07740 4, Inst Pharmacol, D-07740 Jena, Germany
Titolo Testata:
KIDNEY INTERNATIONAL
, volume: 59, anno: 2001, supplemento:, 78
pagine: S262 - S265
SICI:
0085-2538(200102)59:<S262:HIMABV>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
COBALAMIN DEFICIENCY; METHYLMALONIC ACID; RISK FACTOR; HYPERHOMOCYSTEINEMIA; FAILURE; DISEASE; SERUM; RECIPIENTS; PREVALENCE; HYPERHOMOCYST(E)INAEMIA;
Keywords:
kidney transplant; cardiovascular morbidity; uremia; endstage renal disease; B vitamins; allograft outcome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Stein, G Univ Jena, Dept Internal Med 4, Inst Pharmacol, D-07740 Jena, Germany Univ Jena Jena Germany D-07740 Pharmacol, D-07740 Jena, Germany
Citazione:
G. Stein et al., "Homocysteine, its metabolites, and B-group vitamins in renal transplant patients", KIDNEY INT, 59, 2001, pp. S262-S265

Abstract

Background. Increased plasma total homocysteine (tHcy) levels are an independent risk factor for cardiovascular morbidity in patients with normal andimpaired renal function, including stable renal transplant recipients (RTRs). Plasma concentrations of the metabolites of Hey, such as cystathionine (Cys), methylmalonic acid (MMA), 2-methylcitric acid (MC), and its diastereomers MCI and MCII have been reported in only a few articles. We therefore looked for the serum concentration of these metabolites and their relationship to renal function, cardiovascular diseases, the immunosuppressive treatment, and serum concentrations of cobalamin and folate. Methods. Fifty RTRs (mean age 50.4 +/- 11.8 years, 35.9 +/- 44.4 months after kidney transplantation) and 35 controls (NP: mean age 43.5 +/- 14.4 years) were studied. Total Hey and its metabolites were measured by gas chromatography-mass spectrometry (GC-MS). Results. Total Hey, MMA, Cps, and MC were elevated twofold to sixfold as compared with NP, with a significant interrelationship be tween these compounds. With the exception of Cys, they were significantly correlated with serum creatinine. Serum folate levels were inversely correlated with tHcy, Cysand cobalamin with MMA and the ratio of MCI/MCII. There was no correlationbetween tHcy concentration and its metabolites with immunosuppressive treatment (CsA vs. FK506), clinical history, or current findings of cardiovascular complications and blood pressure profile. Conclusion. Prospective studies are needed to find out whether the lowering or normalization of serum concentrations of tHcy and its metabolites due to treatment with B vitamins should be achieved to reduce the cardiovascular risk and improve the long-term outcome of allografts and of patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 23:55:42