Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Dialysis-related amyloidosis of the heart in long-term hemodialysis patients
Autore:
Takayama, F; Miyazaki, S; Morita, T; Hirasawa, Y; Niwa, T;
Indirizzi:
Nagoya Univ, Daiko Med Ctr, Higashi Ku, Nagoya, Aichi 4610047, Japan Nagoya Univ Nagoya Aichi Japan 4610047 i Ku, Nagoya, Aichi 4610047, Japan Shinrakuen Hosp, Niigata, Japan Shinrakuen Hosp Niigata JapanShinrakuen Hosp, Niigata, Japan
Titolo Testata:
KIDNEY INTERNATIONAL
, volume: 59, anno: 2001, supplemento:, 78
pagine: S172 - S176
SICI:
0085-2538(200102)59:<S172:DAOTHI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCATION END-PRODUCTS; SYSTEMIC DISTRIBUTION; BETA(2)-MICROGLOBULIN; DEPOSITION;
Keywords:
calcification of the heart; beta(2)m amyloid deposits; cardiac myocytes; imidazolone; uremia; osteoarticular system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Niwa, T Nagoya Univ, Daiko Med Ctr, Higashi Ku, 1-1-20 Daiko Minami, Nagoya, Aichi4610047, Japan Nagoya Univ 1-1-20 Daiko Minami Nagoya Aichi Japan 4610047 , Japan
Citazione:
F. Takayama et al., "Dialysis-related amyloidosis of the heart in long-term hemodialysis patients", KIDNEY INT, 59, 2001, pp. S172-S176

Abstract

Background. Dialysis-related amyloidosis (DRA) predominantly occurs in theosteoarticular structures, but it also systemically appears in the extra-articular tissues as well. However, the pathological characteristics of DRA in the hearts of hemodialysis (HD) patients have rarely been reported. Methods, We studied the pathological characteristics of DRA in the hearts of 18 HD patients, including its relationship to calcification. Furthermore, we studied the immunuhistochemical localization of advanced glycation endproducts (AGEs) using monoclonal anti-imidazolone and anti-N-epsilon-(carboxy-methyl)lysine (CML) antibodies. Results. beta (2)-microglobulin (beta (2)m) amyloid deposits were detectedin the hearts of seven patients who had undergone HD for more than 10 years. beta (2)m amyloid deposits in the left atrium were localized in the endocardium, the myocardium, and the walls of small blood vessels, whereas in the left ventricle, they were localized only in the walls of small blood vessels. The extent and prevalence of DRA in the heart were severe in the patients on HD fur more than 15 years. Most calcification areas near mitral valve were dotted with beta (2)m amyloid deposits, while diffuse fine calcification was localized within the beta (2)m amyloid tissues in some cases. Imidazolone and CML were localized not only in massive beta (2)m amyloid deposits, but also in cardiac myocytes. Conclusion. DRAs were localized extensively in the hearts: of long-term HDpatients. A strong affinity was observed be tween beta (2)m amyloid deposits and calcification.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:31:34