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Titolo:
Vitamin E, lipid profile, and peroxidation in hemodialysis patients
Autore:
Galli, F; Varga, Z; Balla, J; Ferraro, B; Canestrari, F; Floridi, A; Kakuk, G; Buoncristiani, U;
Indirizzi:
Univ Urbino, Inst Chim Biol G Fornaini, I-61029 Urbino, PS, Italy Univ Urbino Urbino PS Italy I-61029 G Fornaini, I-61029 Urbino, PS, Italy Debrecen Univ Med, Sch Med, Dept Med 1, H-4012 Debrecen, Hungary Debrecen Univ Med Debrecen Hungary H-4012 ed 1, H-4012 Debrecen, Hungary Univ Perugia, Dept Internal Med, I-06100 Perugia, Italy Univ Perugia Perugia Italy I-06100 Internal Med, I-06100 Perugia, Italy Univ Perugia, Dept Metab & Endocrinol Sci, I-06100 Perugia, Italy Univ Perugia Perugia Italy I-06100 ndocrinol Sci, I-06100 Perugia, Italy R Silvestrini Reg Hosp, Nephrol & Dialysis Unit, Perugia, Italy R Silvestrini Reg Hosp Perugia Italy ol & Dialysis Unit, Perugia, Italy
Titolo Testata:
KIDNEY INTERNATIONAL
, volume: 59, anno: 2001, supplemento:, 78
pagine: S148 - S154
SICI:
0085-2538(200102)59:<S148:VELPAP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC-RENAL-FAILURE; SERUM PARAOXONASE ACTIVITY; OXIDATIVE STRESS; UREMIC PATIENTS; OXIDANT STRESS; FATTY-ACIDS; PLASMA; ATHEROSCLEROSIS; HYPERLIPIDEMIA; LEUKOCYTES;
Keywords:
hypertriglyceridemia; plasma fatty acid; atherosclerosis.; cardiovascular disease; oral vitamin supplements; chronic renal failure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Galli, F Univ Urbino, Inst Chim Biol G Fornaini, Via Saffi 2, I-61029 Urbino, PS, Italy Univ Urbino Via Saffi 2 Urbino PS Italy I-61029 Urbino, PS, Italy
Citazione:
F. Galli et al., "Vitamin E, lipid profile, and peroxidation in hemodialysis patients", KIDNEY INT, 59, 2001, pp. S148-S154

Abstract

Background. Hypertriglyceridemia, lipid peroxidation, and abnormalities ofthe plasma fatty acid (PUFA) profile may be important risk factors for theatherosclerotic cardiovascular disease in hemodialysis (HD) patients. Methods. We investigated how these factors are affected by vitamin E supplementation carried out by oral administration (clinical study 1) and dialysis with vitamin E-modified dialyzers (clinical study 2). Results. In the HD patients, conditions of relative vitamin E deficiency were observed [lowered vitamin E/triglyceride (TG) ratio] in the presence ofhigh levels of thiobarbituric acid reactants (TBARs) and decreased levels of the polyunsaturated fraction of PUFAs paired with an increased amount ofmonounsaturated ones (MUFA). In both studies, vitamin E supplementation significantly increased the levels of vitamin E in the plasma without affecting TG levels and provided a partial correction of TEAR levels. Of note was the relative increase in the PUFA fraction, which gave solid pl oof of an anti(pcr)oxidant effect of vitamin E supplementation in FID patients. Vitamin E supplementation was also observed to increase plasma. levels of reducedglutathione and NOx (NO2 + NO3). Conclusion. The results suggest that vitamin E supplementation may be an effective accessory therapy to combat oxidative stress-lowering lipid peroxidation in IID patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:37:05