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Titolo:
Efficacy and tolerability of angiotensin II type 1 receptor antagonists indialysis patients using AN69 dialysis membranes
Autore:
Tepel, M; van der Giet, M; Zidek, W;
Indirizzi:
Ruhr Univ Bochum, Marienhosp, Med Klin 1, D-44625 Herne, Germany Ruhr UnivBochum Herne Germany D-44625 ed Klin 1, D-44625 Herne, Germany
Titolo Testata:
KIDNEY & BLOOD PRESSURE RESEARCH
fascicolo: 1, volume: 24, anno: 2001,
pagine: 71 - 74
SICI:
1420-4096(2001)24:1<71:EATOAI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANAPHYLACTOID REACTIONS; HEMODIALYSIS; LOSARTAN; INHIBITORS; BRADYKININ;
Keywords:
angiotensin receptor antagonists; end-stage renal failure; hypertension;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Tepel, M Ruhr Univ Bochum, Marienhosp, Med Klin 1, Holkeskampring 40, D-44625 Herne, Germany Ruhr Univ Bochum Holkeskampring 40 Herne Germany D-44625 Germany
Citazione:
M. Tepel et al., "Efficacy and tolerability of angiotensin II type 1 receptor antagonists indialysis patients using AN69 dialysis membranes", KIDNEY BL P, 24(1), 2001, pp. 71-74

Abstract

Aims and Methods: Our aim was to evaluate the antihypertensive efficacy and tolerability of angiotensin II type 1 (AT(1)) receptor antagonists. Valsartan or candesartan cilexetil was administered to 11 dialysis patients withelevated blood pressure. The patients (6 male, 5 female; mean age +/- SD 61 +/- 11 years) were on regular bicarbonate hemodialysis three times weeklyfor more than 3 months using acrylonitrile and sodium methallyl sulfonate copolymer (AN69) dialysis membranes. Results: Within 252 days after administration of the ATI receptor antagonists the systolic blood pressure was significantly reduced from 161+/-13 to 130+/-12 mm Hg (p<0.001), whereas the diastolic blood pressure did not change significantly (76+/-8 vs. 71+/-8 mmHg; p>0.05). In addition, heart rate (75+/-7 vs. 80+/-9/min), body weight, and laboratory variables (hemoglobin, creatinine, blood urea nitrogen, serumpotassium, serum sodium, serum calcium, and total protein) showed no significant changes. During 1,188 hemodialysis sessions using AN69 membranes, nohypersensitivity reactions occurred after administration of AT1 receptor antagonists. Conclusion: The results indicate that once-daily administrationof AT1 receptor antagonists efficiently reduces the systolic blood pressure in hemodialysis patients. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:04:10