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Titolo:
Thiazide-sensitive cotransporter mRMA expression is not altered in three models of hypertension
Autore:
Moreno, G; Bobadilla, NA; Gonzalez-Salazar, J; Mercado, A; Tapia, E; Hong, E; Herrera-Acosta, J; Gamba, G;
Indirizzi:
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mol Physiol Unit, Tlalpan 14000, Mexico Inst Nacl Ciencias Med & Nutr Salvador Zubiran Tlalpan Mexico 14000 xico Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City 04510, DF, Mexico Univ Nacl Autonoma Mexico Mexico City DF Mexico 04510 y 04510, DF, Mexico Inst Nacl Cardiol Ignacio Chavez, Dept Nephrol, Mexico City, DF, Mexico Inst Nacl Cardiol Ignacio Chavez Mexico City DF Mexico City, DF, Mexico IPN, CINVESTAV, Dept Pharmacol & Toxicol, Mexico City 07738, DF, Mexico IPN Mexico City DF Mexico 07738 & Toxicol, Mexico City 07738, DF, Mexico
Titolo Testata:
KIDNEY & BLOOD PRESSURE RESEARCH
fascicolo: 1, volume: 24, anno: 2001,
pagine: 57 - 63
SICI:
1420-4096(2001)24:1<57:TCMEIN>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPITHELIAL SODIUM-CHANNEL; NA-CL COTRANSPORTER; BARTTERS-SYNDROME; BLOOD-PRESSURE; HYPOKALEMIC ALKALOSIS; SEMIQUANTITATIVE PCR; MUTATIONS; KIDNEY; RATS; NATRIURESIS;
Keywords:
thiazide; gene expression; hypertension; thiazide-sensitive cotransporter;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Gamba, G Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mol Physiol Unit,Vasco Quiroga 15, Tlalpan 14000, Mexico Inst Nacl Ciencias Med & Nutr Salvador Zubiran Vasco Quiroga 15 Tlalpan Mexico 14000
Citazione:
G. Moreno et al., "Thiazide-sensitive cotransporter mRMA expression is not altered in three models of hypertension", KIDNEY BL P, 24(1), 2001, pp. 57-63

Abstract

Background/Aims: Several fines of evidence support that the kidney is involved in the increase of arterial blood pressure, and some genetic studies suggest that the thiazide-sensitive Na+:Cl- cotransporter could be implicated in the development of hypertension. In the present study, we analyzed theNa+:Cl- cotransporter mRNA levels in the kidney during the development of hypertension in three experimental models. Methods: The first model included 18 spontaneously hypertensive rats studied at 4, 10, and 16 weeks of age. The second model included 28 Wistar rats with two-kidney, one-clip Goldblatt hypertension studied at 7, 14, 21, and 28 days. The third model included6 Wistar rats treated with N-G-nitro-L-arginine methyl ester during 10 days. Respective controls were studied for all models. At the end of each experimental period, the systolic blood pressure was measured in the tail by plethysmography. individual renal cortex tota I RNA was extracted, and the mRNA levels of the thiazide-sensitive Na+:Cl- cotransporter were assessed following a semiquantitative RT-PCR strategy. Results: All experimental modelsdeveloped systemic hypertension. However, the level of mRNA expression of the Na+:Cl- cotransporter did not change in any of the models studied as compared with their respective controls. Conclusion: Our results suggest thata change in mRNA levels of the thiazide-sensitive Na+:Cl- cotransporter isnot associated with the development of hypertension in spontaneously hypertensive rats, in rats with renovascular hypertension, nor in rats with hypertension induced by nitric oxide synthesis inhibition. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 15:05:48