Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Extracorporeal detoxification using the molecular adsorbent recirculating system for critically ill patients with liver failure
Autore:
Mitzner, SR; Stange, J; Klammt, S; Peszynski, P; Schmidt, R; Noldge-Schomburg, G;
Indirizzi:
Univ Rostock, Dept Med, Div Nephrol, D-18055 Rostock, Germany Univ Rostock Rostock Germany D-18055 v Nephrol, D-18055 Rostock, Germany Univ Rostock, Dept Med, Div Gastroenterol, Rostock, Germany Univ Rostock Rostock Germany t Med, Div Gastroenterol, Rostock, Germany Univ Rostock, Dept Anesthesiol & Intens Care Med, Rostock, Germany Univ Rostock Rostock Germany hesiol & Intens Care Med, Rostock, Germany
Titolo Testata:
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
fascicolo: 2, volume: 12, anno: 2001, supplemento:, 17
pagine: S75 - S82
SICI:
1046-6673(200102)12:2<S75:EDUTMA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE HEPATIC-FAILURE; HUMAN SERUM-ALBUMIN; NITRIC-OXIDE; BIOARTIFICIAL LIVER; OBSTRUCTIVE-JAUNDICE; RAT HEPATOCYTES; RENAL-FUNCTION; BILE-ACIDS; TRANSPLANTATION; ENCEPHALOPATHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Mitzner, SR Univ Rostock, Dept Med, Div Nephrol, E Heydemann Str 6, D-18055 Rostock, Germany Univ Rostock E Heydemann Str 6 Rostock Germany D-18055 ermany
Citazione:
S.R. Mitzner et al., "Extracorporeal detoxification using the molecular adsorbent recirculating system for critically ill patients with liver failure", J AM S NEPH, 12(2), 2001, pp. S75-S82

Abstract

Liver failure resulting from different causes and its concomitant complications represent difficult-to-treat conditions with high mortality rates, despite improved therapeutic modalities in intensive care medicine. The accumulation of albumin-bound metabolites that are normally cleared by the liver, such as bilirubin and bile acids, contributes substantially to the development of multiorgan dysfunction in these clinical situations. The molecularadsorbent recirculating system (MARS) represents a cell-free, extracorporeal, liver assistance method for the selective removal of albumin-bound substances. Moreover, it enables the removal of excess water and water-soluble substances via an inbuilt dialysis step. Since 1993, >400 patients have been treated in 53 centers in Europe, the United States, and Asia. Diseases treated with MARS included acute exacerbation of chronic hepatic failure, hepatorenal syndrome, acute hepatic failure, and primary nonfunction/poor function after liver transplantation and major liver resection. Treatments werewell tolerated. No severe adverse events were observed. Six- to 8-h MARS treatments resulted in significant (P < 0.05) removal of bilirubin, bile acids, tryptophan, short- and middle-chain fatty acids, aromatic amino acids, and ammonia. Clearance rates for strongly albumin-bound substances were between 10 and 60 ml/min. The removal of albumin-bound toxins resulted in decreases in hepatic encephalopathy, increases in mean arterial pressure, and improvements in kidney and liver function. In the first randomized clinical trial of the MARS method for treatment of the hepatorenal syndrome, significant prolongation of survival was observed for the MARS-treated group. It is concluded that the MARS method can contribute to the treatment of critically ill patients with liver failure and different underlying diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 02:25:28