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Titolo:
L-arginine supplementation improves function and reduces inflammation in renal allografts
Autore:
Vos, IHC; Rabelink, TJ; Dorland, B; Loos, R; Van Middelaar, B; Grone, HJ; Joles, JA;
Indirizzi:
Univ Utrecht, Med Ctr, Dept Vasc Med, NL-3584 CX Utrecht, Netherlands UnivUtrecht Utrecht Netherlands NL-3584 CX 3584 CX Utrecht, Netherlands Univ Utrecht, Med Ctr, Dept Hypertens & Nephrol, NL-3584 CX Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 CX 3584 CX Utrecht, Netherlands Wilhelmina Childrens Hosp, Lab Metab Dis, Utrecht, Netherlands Wilhelmina Childrens Hosp Utrecht Netherlands Dis, Utrecht, Netherlands German Canc Res Ctr, Dept Cellular & Mol Pathol, D-6900 Heidelberg, Germany German Canc Res Ctr Heidelberg Germany D-6900 D-6900 Heidelberg, Germany
Titolo Testata:
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
fascicolo: 2, volume: 12, anno: 2001,
pagine: 361 - 367
SICI:
1046-6673(200102)12:2<361:LSIFAR>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIA-REPERFUSION INJURY; VASCULAR ENDOTHELIAL-CELLS; NITRIC-OXIDE SYNTHASE; DIETARY SUPPLEMENTATION; OBSTRUCTIVE NEPHROPATHY; CHRONIC REJECTION; KIDNEY; RAT; FAILURE; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Rabelink, TJ Univ Utrecht, Med Ctr, Dept Vasc Med, Fo2-126,Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands Univ Utrecht Fo2-126,Heidelberglaan 100 Utrecht Netherlands NL-3584 CX
Citazione:
I.H.C. Vos et al., "L-arginine supplementation improves function and reduces inflammation in renal allografts", J AM S NEPH, 12(2), 2001, pp. 361-367

Abstract

Recovery from ischemia/reperfusion and immune-mediated injury in the renaltransplant is associated with reduced renal hemodynamics and increased leukocyte infiltration. In diverse models of renal failure, L-arginine supplementation improved hemodynamics and reduced inflammation. However in a proinflammatory environment, L-arginine can worsen renal injury. This study investigated the therapeutic potential of L-arginine supplementation in allogeneic renal transplantation: Brown Norway rat kidneys were transplanted into Lewis rat recipients, with one native kidney remaining. Recipients receivedlow-dose cyclosporin A (2.5 mg/kg per d subcutaneously) to obtain moderatevascular and interstitial rejection, with or without 1% L-arginine in drinking water for 7 d posttransplantation. Transplantation increased renal vasoconstriction (from 16.9 +/- 1.33 to 35.1 +/- 8.6 units; P < 0.01), therebyreducing GER (from 0.96 +/- 0.09 to 0.48 +/- 0.10 ml/min; P < 0.05). Treatment with L-arginine restored renal graft function to levels found in normal donors (renal vascular resistance, 15.7 +/- 1.69 units; GFR, 0.80 +/- 0.06 ml/min). L-arginine significantly reduced vascular occlusion because of less inflammation, endothelial disruption, and thrombosis. L-arginine also decreased tubulitis, interstitial injury, and macrophage infiltration. Theseprotective effects suggest that L-arginine might be useful as additive therapy to conventional immune suppression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:37:16