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Titolo:
Characterization of the product ions from the collision-induced dissociation of argentinated peptides
Autore:
Chu, IK; Shoeib, T; Guo, X; Rodriquez, CF; Lan, TC; Hopkinson, AC; Siu, KWM;
Indirizzi:
York Univ, Dept Chem, Toronto, ON M3J 2R7, Canada York Univ Toronto ON Canada M3J 2R7 ept Chem, Toronto, ON M3J 2R7, Canada York Univ, Ctr Res Mass Spectrometry, Toronto, ON M3J 2R7, Canada York Univ Toronto ON Canada M3J 2R7 trometry, Toronto, ON M3J 2R7, Canada City Univ Hong Kong, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R ChinaCity Univ Hong Kong Kowloon Hong Kong Peoples R China g, Peoples R China
Titolo Testata:
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
fascicolo: 2, volume: 12, anno: 2001,
pagine: 163 - 175
SICI:
1044-0305(200102)12:2<163:COTPIF>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
TANDEM MASS-SPECTROMETRY; SURFACE-INDUCED DISSOCIATION; EFFECTIVE CORE POTENTIALS; SALT-BRIDGE STRUCTURES; GAS-PHASE; PROTONATED PEPTIDES; ELECTROSPRAY-IONIZATION; FRAGMENTATION EFFICIENCY; MOLECULAR CALCULATIONS; AMIDE BOND;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
89
Recensione:
Indirizzi per estratti:
Indirizzo: Siu, KWM York Univ, Dept Chem, Toronto, ON M3J 2R7, Canada York Univ Toronto ON Canada M3J 2R7 Toronto, ON M3J 2R7, Canada
Citazione:
I.K. Chu et al., "Characterization of the product ions from the collision-induced dissociation of argentinated peptides", J AM SOC M, 12(2), 2001, pp. 163-175

Abstract

Tandem mass spectrometry performed on a pool of 18 oligopeptides shows that the product ion spectra of argentinated peptides, the [b,, + OH + Ag](+) ions and the [y(n) - H + Ag](+) ions bearing identical sequences are virtually identical. These observations suggest strongly that these ions have identical structures in the gas phase. The structures of argentinated glycine,glycylglycine, and glycylglycylglycine were calculated using density functional theory (DFT) at the B3LYP/DZVP level of theory; they were independently confirmed using HF/LANL2DZ. For argentinated glycylglycylglycine, the most stable structure is one in which Ag+ is tetracoordinate and attached to the amino nitrogen and the three carbonyl oxygen atoms. Mechanisms are proposed for the fragmentation of this structure to the [b(2) + OH + Ag](+) andthe [y(2) - H + Ag]+ ions that are consistent with all experimental observations and known calculated structures and energetics. The structures of the [b(2) - H + Ag](+) and the [a(2) - H + Ag](+) ions of glycylglycylglycinewere also calculated using DFT. These results confirm earlier suggestions that the [b(2) - H + Ag](+) ion is an argentinated oxazolone and the [a(2) - H + Ag](+) an argentinated immonium ion. (C) 2001 American Society for Mass Spectrometry.

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Documento generato il 30/03/20 alle ore 18:28:38