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Titolo:
Expression of Fas ligand is an early event in colorectal carcinogenesis
Autore:
Shimoyama, M; Kanda, T; Liu, LL; Koyama, Y; Suda, T; Sakai, Y; Hatakeyama, K;
Indirizzi:
Niigata Univ, Sch Med, Dept Surg, Niigata 9518510, Japan Niigata Univ Niigata Japan 9518510 ed, Dept Surg, Niigata 9518510, Japan
Titolo Testata:
JOURNAL OF SURGICAL ONCOLOGY
fascicolo: 1, volume: 76, anno: 2001,
pagine: 63 - 68
SICI:
0022-4790(200101)76:1<63:EOFLIA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN COLON-CANCER; IMMUNE EVASION; DEATH FACTOR; APOPTOSIS; COUNTERATTACK; MECHANISM; CELLS; ADENOCARCINOMAS;
Keywords:
FasL; colorectal cancer; colorectal adenoma; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Kanda, T Niigata Univ, Sch Med, Dept Surg, 1-757 Asahimachi-dori, Niigata 9518510, Japan Niigata Univ 1-757 Asahimachi-dori Niigata Japan 9518510 , Japan
Citazione:
M. Shimoyama et al., "Expression of Fas ligand is an early event in colorectal carcinogenesis", J SURG ONC, 76(1), 2001, pp. 63-68

Abstract

Background and Objectives: Fas ligand (FasL) is expressed in many cancers and plays an important role in establishing immunologically privileged environments that allow tumors to escape the host's immune surveillance. We investigate the expression of FasL in human colorectal cancer and colorectal adenoma and elucidate the relationship between FasL expression and the clinicopathological characteristics of colorectal cancers. Methods: We examined 214 colorectal cancer specimens and 83 colorectal adenoma specimens. Expression of FasL was determined by immunohistochemical staining using a specific monoclonal antibody. We analyzed the relationship between the results of FasL expression and clinicopathological data statistically. Results: FasL expression was detected in 173 (80.8%) of 214 colorectal carcinomas and 34 (40.9%) of 83 colorectal adenomas. The status of FasL expression in colorectal carcinoma was independent of clinicopathological features including tumor stage, histologic grade. lymphatic invasion, venous invasion, lymph node metastasis, liver metastasis, and Dukes stage. In colorectal adenoma, FasL expression was more frequently observed in high-grade atypia than in low-grade atypia (P = 0.05). Conclusions: FasL expression is commonly observed not only in cancer but also in highly dysplastic tissue. These observations suggest that FasL expression may be an important event in the transformation process leading to adenocarcinoma. J, Surg. Oncol. 2001:76:63-68. (C) 2001 Wiley-Liss. Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 00:09:05