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Titolo:
Excessive activation of serotonin (5-HT) 1B receptors disrupts the formation of sensory maps in monoamine oxidase a and 5-HT transporter knock-out mice
Autore:
Salichon, N; Gaspar, P; Upton, AL; Picaud, S; Hanoun, N; Hamon, M; De Maeyer, E; Murphy, DL; Mossner, R; Lesch, KP; Hen, R; Seif, I;
Indirizzi:
Inst Curie, CNRS, Unite Mixte Rech 146, F-91405 Orsay, France Inst Curie Orsay France F-91405 te Mixte Rech 146, F-91405 Orsay, France Hop La Pitie Salpetriere, INSERM, U106, F-75651 Paris, France Hop La PitieSalpetriere Paris France F-75651 106, F-75651 Paris, France Hop La Pitie Salpetriere, INSERM, U288, F-75634 Paris, France Hop La PitieSalpetriere Paris France F-75634 288, F-75634 Paris, France NIMH, Clin Sci Lab, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892NIMH, Clin Sci Lab, Bethesda, MD 20892 USA Univ Wurzburg, Dept Psychiat & Psychotherapy, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 herapy, D-97080 Wurzburg, Germany Columbia Univ, Ctr Neurobiol & Behav, New York, NY 10032 USA Columbia Univ New York NY USA 10032 obiol & Behav, New York, NY 10032 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 3, volume: 21, anno: 2001,
pagine: 884 - 896
SICI:
0270-6474(20010201)21:3<884:EAOS(1>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SOMATOSENSORY CORTEX; LESION-INDUCED REORGANIZATION; SPONTANEOUS RETINAL ACTIVITY; VIBRISSAE-RELATED PATTERNS; VISUAL-SYSTEM DEVELOPMENT; CENTRAL-NERVOUS-SYSTEM; POSTNATAL-DEVELOPMENT; CORTICAL ACTIVITY; SUBCELLULAR-LOCALIZATION; THALAMOCORTICAL AXONS;
Keywords:
5-HT1B receptor; monoamine oxidase; serotonin transporter; activity-dependent development; retinal projections; dorsal lateral geniculate nucleus; thalamocortical; barrel field;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Seif, I Inst Curie, CNRS, Unite Mixte Rech 146, F-91405 Orsay, France InstCurie Orsay France F-91405 Rech 146, F-91405 Orsay, France
Citazione:
N. Salichon et al., "Excessive activation of serotonin (5-HT) 1B receptors disrupts the formation of sensory maps in monoamine oxidase a and 5-HT transporter knock-out mice", J NEUROSC, 21(3), 2001, pp. 884-896

Abstract

Deficiency in the monoamine degradation enzyme monoamine oxidase A (MAOA) or prenatal exposure to the monoamine uptake inhibitor cocaine alters behavior in humans and rodents, but the mechanisms are unclear. In MAOA knock-out mice, inhibiting serotonin synthesis during development can prevent abnormal segregation of axons in the retinogeniculate and somatosensory thalamocortical systems. To investigate this effect, we crossed MAOA knock-outs with mice lacking the serotonin transporter 5-HTT or the 5-HT1B receptor, two molecules present in developing sensory projections. Segregation was abnormal in 5-HTT knock-outs and MAOA/5-HTT double knock-outs but was normalized in MAOA/5-HT1B double knock-outs and MAOA/5-HTT/5-HT1B triple knock-outs. This demonstrates that the 5-HT1B receptor is a key factor in abnormal segregation of sensory projections and suggests that serotonergic drugs represent a risk for the development of these projections. We also found that the 5-HT1B receptor has an adverse developmental impact on beam-walking behaviorin MAOA knock-outs. Finally, because the 5-HT1B receptor inhibits glutamate release, our results suggest that visual and somatosensory projections must release glutamate for proper segregation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:15:17