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Titolo:
Theta-frequency bursting and resonance in cerebellar granule cells: Experimental evidence and modeling of a slow K+-dependent mechanism
Autore:
DAngelo, E; Nieus, T; Maffei, A; Armano, S; Rossi, P; Taglietti, V; Fontana, A; Naldi, G;
Indirizzi:
Univ Pavia, Dept Cellular & Mol Physiol, I-27100 Pavia, Italy Univ Pavia Pavia Italy I-27100 lular & Mol Physiol, I-27100 Pavia, Italy Univ Pavia, Inst Nazl Fis Mat, I-27100 Pavia, Italy Univ Pavia Pavia Italy I-27100 , Inst Nazl Fis Mat, I-27100 Pavia, Italy Univ Parma, Dept Evolutionary & Funct Biol, I-43100 Parma, Italy Univ Parma Parma Italy I-43100 ionary & Funct Biol, I-43100 Parma, Italy Univ Pavia, Dept Nucl & Theoret Phys, I-27100 Pavia, Italy Univ Pavia Pavia Italy I-27100 Nucl & Theoret Phys, I-27100 Pavia, Italy Univ Milan Bicocca, Dept Math & Applicat, Milan, Italy Univ Milan BicoccaMilan Italy occa, Dept Math & Applicat, Milan, Italy
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 3, volume: 21, anno: 2001,
pagine: 759 - 770
SICI:
0270-6474(20010201)21:3<759:TBARIC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; VOLTAGE-CLAMP DATA; IN-SITU; ELECTROPHYSIOLOGICAL PROPERTIES; NEOCORTICAL NEURONS; PYRAMIDAL CELLS; RAT CEREBELLUM; SODIUM CURRENT; ACTIVATION; OSCILLATIONS;
Keywords:
bursting; resonance; M-current; cerebellum; granule cell; modeling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: D'Angelo, E Dept Cellular Mol Physiol & Pharmacol, Via Forlanini 6, I-27100 Pavia, Italy Dept Cellular Mol Physiol & Pharmacol Via Forlanini 6 PaviaItaly I-27100
Citazione:
E. D'Angelo et al., "Theta-frequency bursting and resonance in cerebellar granule cells: Experimental evidence and modeling of a slow K+-dependent mechanism", J NEUROSC, 21(3), 2001, pp. 759-770

Abstract

Neurons process information in a highly nonlinear manner, generating oscillations, bursting, and resonance, enhancing responsiveness at preferential frequencies. It has been proposed that slow repolarizing currents could be responsible for both oscillation/burst termination and for high-pass filtering that causes resonance (Hutcheon and Yarom, 2000). However, different mechanisms, including electrotonic effects (Mainen and Sejinowski, 1996), theexpression of resurgent currents (Raman and Bean, 1997), and network feedback, may also be important. In this study we report theta-frequency (3-12 Hz) bursting and resonance in rat cerebellar granule cells and show that these neurons express a previously unidentified slow repolarizing K+ current (IK-slow). Our experimental and modeling results indicate that IK-slow was necessary for both bursting and resonance. A persistent (and potentially a resurgent) Na+ current exerted complex amplifying actions on bursting and resonance, whereas electrotonic effects were excluded by the compact structure of the granule cell. Theta-frequency bursting and resonance in granule cells may play an important role in determining synchronization, rhythmicity,and learning in the cerebellum.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/10/20 alle ore 22:34:55