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Titolo:
Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motor
Autore:
Yano, H; Lee, FS; Kong, H; Chuang, JZ; Arevalo, JC; Perez, P; Sung, CH; Chao, MV;
Indirizzi:
NYU, Sch Med, Skirball Inst Biomol Med, Dept Cell Biol & Physiol,Mol Neurobiol Program, New York, NY 10016 USA NYU New York NY USA 10016 l,Mol Neurobiol Program, New York, NY 10016 USA NYU, Sch Med, Skirball Inst Biomol Med, Dept Neurosci,Mol Neurobiol Program, New York, NY 10016 USA NYU New York NY USA 10016 i,Mol Neurobiol Program, New York, NY 10016 USA Cornell Univ, Weill Med Coll, Margaret M Dyson Vis Res Inst, Dept Cell Biol, New York, NY 10021 USA Cornell Univ New York NY USA 10021 Dept Cell Biol, New York, NY 10021 USA Cornell Univ, Weill Med Coll, Margaret M Dyson Vis Res Inst, Dept Anat, New York, NY 10021 USA Cornell Univ New York NY USA 10021 nst, Dept Anat, New York, NY 10021 USA Cornell Univ, Weill Med Coll, Margaret M Dyson Vis Res Inst, Dept Ophthalmol, New York, NY 10021 USA Cornell Univ New York NY USA 10021 ept Ophthalmol, New York, NY 10021 USA Univ Salamanca, CSIC, Inst Microbiol Bioquim, Salamanca 37007, Spain Univ Salamanca Salamanca Spain 37007 iol Bioquim, Salamanca 37007, Spain
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 3, volume: 21, anno: 2001,
pagine: NIL_7 - NIL_13
SICI:
0270-6474(20010201)21:3<NIL_7:AOTNRW>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; RETROGRADE AXONAL-TRANSPORT; LIGHT-CHAIN; SYMPATHETIC NEURONS; TCTEX-1; COMPLEX; PROTEINS; SIGNAL; SYSTEM; KINASE;
Keywords:
NGF; Trk receptor; cytoplasmic dynein; retrograde transport; sciatic nerve; ligation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Chao, MV NYU, Sch Med, Skirball Inst Biomol Med, Dept Cell Biol & Physiol,Mol Neurobiol Program, 540 1st Ave, New York, NY 10016 USA NYU 540 1st Ave New York NY USA 10016 Ave, New York, NY 10016 USA
Citazione:
H. Yano et al., "Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motor", J NEUROSC, 21(3), 2001, pp. NIL_7-NIL_13

Abstract

Nerve growth factor (NGF) initiates its trophic effects by long-range signaling through binding, internalization, and transport of a ligand-receptor complex from the axon terminal to the cell body. However, the mechanism by which retrograde transport of NGF takes place has not been elucidated. Herewe describe an interaction between the Trk receptor tyrosine kinase and a 14 kDa light chain of cytoplasmic dynein. After transfection in human embryonic kidney 293 cells, this 14 kDa dynein light chain was found to bind to TrkA, TrkB, and TrkC receptors. Mapping experiments indicated that the 14 kDa dynein light chain binds to the distal region of the TrkA juxtamembrane domain. Coimmunoprecipitation experiments in vivo indicate that Trk receptors are in a complex with the 14 kDa light chain and 74 kDa intermediate chain of dynein. Confirming the physiological relevance of this association, amarked accumulation of Trk with the 14 kDa and the 74 kDa dynein components was observed after ligation of the sciatic nerve. The association of Trk receptors with components of cytoplasmic dynein suggests that transport of neurotrophins during vesicular trafficking may occur through a direct interaction of the Trk receptor with the dynein motor machinery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 09:13:32