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Titolo:
Serotonin effects on frequency tuning of inferior colliculus neurons
Autore:
Hurley, LM; Pollak, GD;
Indirizzi:
Univ Texas, Neurobiol Sect, Austin, TX 78712 USA Univ Texas Austin TX USA78712 exas, Neurobiol Sect, Austin, TX 78712 USA
Titolo Testata:
JOURNAL OF NEUROPHYSIOLOGY
fascicolo: 2, volume: 85, anno: 2001,
pagine: 828 - 842
SICI:
0022-3077(200102)85:2<828:SEOFTO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREE-TAILED BAT; TADARIDA-BRASILIENSIS-MEXICANA; SUPERIOR OLIVARY COMPLEX; PRIMARY AUDITORY-CORTEX; CENTRAL-NERVOUS-SYSTEM; RAPHE UNIT-ACTIVITY; BRAIN-STEM; DESCENDING PROJECTIONS; COCHLEAR NUCLEUS; CHOLINERGIC RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Hurley, LM Univ Texas, Neurobiol Sect, C0920 Patterson 140, Austin, TX 78712 USA Univ Texas C0920 Patterson 140 Austin TX USA 78712 TX 78712 USA
Citazione:
L.M. Hurley e G.D. Pollak, "Serotonin effects on frequency tuning of inferior colliculus neurons", J NEUROPHYS, 85(2), 2001, pp. 828-842

Abstract

We investigated the modulatory effects of serotonin on the tuning of 114 neurons in the central nucleus of the inferior colliculus (ICc) of Mexican free-tailed bats and how serotonin-induced changes in tuning influenced responses to complex signals. We obtained a "response area" for each neuron, defined as the frequency range that evoked discharges and the spike counts evoked by those frequencies at a constant intensity. We then iontophoretically applied serotonin and compared response areas obtained before and during the application of serotonin. In 58 cells, we also assessed how serotonin-induced changes in response areas correlated with changes in the responses to brief frequency-modulated (FM) sweeps whose structure simulated natural echolocation calls. Serotonin profoundly changed tone-evoked spike counts in60% of the neurons (68/114). In most neurons, serotonin exerted a gain control, facilitating or depressing the responses to all frequencies in their response areas. In many cells, serotonergic effects on tones were reflectedin the responses to FM signals. The most interesting effects were in thosecells in which serotonin selectively changed the responsiveness to only some frequencies in the neuron's response area and had little or no effect onother frequencies. This caused predictable changes in responses to the more complex FM sweeps whose spectral components passed through the neurons' response areas. Our results suggest that serotonin, whose release varies with behavioral state, functionally reconfigures the circuitry of the IC and may modulate the perception of acoustic signals under different behavioral states.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 05:15:11