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Titolo:
Effects of glucocorticoids on adrenal chromaffin cells
Autore:
Hodel, A;
Indirizzi:
Univ Cambridge, Dept Pharmacol, Cambridge CB2 1QJ, England Univ CambridgeCambridge England CB2 1QJ col, Cambridge CB2 1QJ, England
Titolo Testata:
JOURNAL OF NEUROENDOCRINOLOGY
fascicolo: 2, volume: 13, anno: 2001,
pagine: 217 - 221
SICI:
0953-8194(200102)13:2<217:EOGOAC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; PHENYLETHANOLAMINE N-METHYLTRANSFERASE; MEDULLARY CELLS; MESSENGER-RNA; RESPONSE ELEMENT; RAT; DEXAMETHASONE; RECEPTOR; GLAND; GENE;
Keywords:
glucocorticoids; glucocorticoid receptor; chromaffin cell; adrenal gland;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Hodel, A Univ Cambridge, Dept Pharmacol, Tennis Court Rd, Cambridge CB2 1QJ, England Univ Cambridge Tennis Court Rd Cambridge England CB2 1QJ England
Citazione:
A. Hodel, "Effects of glucocorticoids on adrenal chromaffin cells", J NEUROENDO, 13(2), 2001, pp. 217-221

Abstract

The mammalian adrenal gland consists of two anatomically distinct parts: an outer cortex that synthesizes steroids and a central medulla that contains catecholamine-producing chromaffin cells. Although derived from differentembryological origins, the two secretory tissues in the adult animal are functionally as well as structurally linked. Glucocorticoids, a class of steroid hormones produced by the cortex, exert a variety of effects on medullary chromaffin cells, They modulate the expression of specific genes via activation of glucocorticoid receptors that act as transcription factors and either up- or down-regulate mRNA synthesis. The direct binding to and modulation of cation channels by glucocorticoids as well as the control of mRNA or protein stability are other proposed mechanisms of glucocorticoid action. The activity of phenylethanolamine N-methyltransferase, the enzyme that converts noradrenaline into adrenaline, is stimulated by glucocorticoids, which causes the conversion of noradrenergic to adrenergic chromaffin cells. Other phenotypic manifestations of glucocorticoid action include the upregulation of catecholamine synthesis, storage, and secretion. Furthermore, glucocorticoids have been implicated in chromaffin cell differentiation. However, recent gene knockout experiments suggest that glucocorticoid signalling is required only for the acquisition of the adrenergic but not the noradrenergic phenotype.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:12:17