Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Actions of leptin on growth hormone secretagogue-responsive neurones in the rat hypothalamic arcuate nucleus recorded in vitro
Autore:
Tung, YCL; Hewson, AK; Dickson, SL;
Indirizzi:
Univ Cambridge, Dept Physiol, Cambridge CB2 3EG, England Univ Cambridge Cambridge England CB2 3EG iol, Cambridge CB2 3EG, England
Titolo Testata:
JOURNAL OF NEUROENDOCRINOLOGY
fascicolo: 2, volume: 13, anno: 2001,
pagine: 209 - 215
SICI:
0953-8194(200102)13:2<209:AOLOGH>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; GH-RELEASING PEPTIDE-6; OBESE GENE-PRODUCT; NEUROPEPTIDE-Y; PARAVENTRICULAR NUCLEUS; FOS EXPRESSION; FOOD-INTAKE; OB/OB MICE; RECEPTOR; SECRETION;
Keywords:
neuropeptide Y; growth hormone releasing hormone; feeding; GHRP-6; ghrelin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Dickson, SL Univ Cambridge, Dept Physiol, Downing St, Cambridge CB2 3EG, England Univ Cambridge Downing St Cambridge England CB2 3EG , England
Citazione:
Y.C.L. Tung et al., "Actions of leptin on growth hormone secretagogue-responsive neurones in the rat hypothalamic arcuate nucleus recorded in vitro", J NEUROENDO, 13(2), 2001, pp. 209-215

Abstract

In the arcuate nucleus, the growth hormone (GH) secretagogue (GHS)-responsive cells include a subpopulation of the neuropeptide Y (NPY) neurones. It is not known whether these include the orexigenic NPY population that are inhibited by the satiety hormone, leptin. Thus we investigated whether (i) the arcuate nucleus cells electrically excited by GHS are inhibited by leptin and(ii) chronic central leptin infusion alters GHS-induced Fos expression. Of 36 cells recorded from a trimmed hypothalamic slice containing arcuatenucleus, 13 cells were excited by the nonpeptide GHS, CP-459,599. The predominant response of these cells to leptin was inhibitory: six inhibited, three excited and four unresponsive. Similar responses were observed in a population of arcuate cells recorded from a preparation in which synaptic transmission was blocked, suggesting that leptin acts directly on a subpopulation of GHS-responsive neurones. Intracerebroventricular infusion of leptin for 1 week did not alter the number of cells expressing Fos following GHS administration. Thus, while leptin does not appear to influence the central actions of GHS to induce immediate early gene expression, it does act directly on a subpopulation of cells excited by GHS, eliciting mostly inhibitory but also some excitatory responses. It will be interesting to discover the consequences of leptin's inhibitory effects on the hypothalamic circuits excited by GHS, particularly since leptin paradoxically has a stimulatory effect on GH secretion, presumed to reflect a suppression of central NPY pathways.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:36:35