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Titolo:
Effects of testosterone on the electrical properties and nicotinic transmission of the major pelvic and coeliac ganglion neurones
Autore:
Felix, B; Catalin, D; Miolan, JP; Niel, JP;
Indirizzi:
INRA, Lab Neurobiol Fonct Vegetat, U1060, F-78352 Jouy En Josas, France INRA Jouy En Josas France F-78352 , U1060, F-78352 Jouy En Josas, France Fac Sci & Tech St Jerome, CNRS, Dept Physiol & Neurophysiol, F-13397 Marseille, France Fac Sci & Tech St Jerome Marseille France F-13397 3397 Marseille, France
Titolo Testata:
JOURNAL OF NEUROENDOCRINOLOGY
fascicolo: 2, volume: 13, anno: 2001,
pagine: 193 - 198
SICI:
0953-8194(200102)13:2<193:EOTOTE>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; INTEGRATIVE PROPERTIES; SYMPATHETIC NEURONS; TYROSINE-HYDROXYLASE; MALE-RAT; RABBIT; 17-BETA-ESTRADIOL; RECEPTOR;
Keywords:
prevertebral ganglia; testosterone; neuronal electrical properties; synaptic transmission;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Felix, B INRA, Lab Neurobiol Fonct Vegetat, U1060, F-78352 Jouy En Josas, France INRA Jouy En Josas France F-78352 F-78352 Jouy En Josas, France
Citazione:
B. Felix et al., "Effects of testosterone on the electrical properties and nicotinic transmission of the major pelvic and coeliac ganglion neurones", J NEUROENDO, 13(2), 2001, pp. 193-198

Abstract

The effects of testosterone on the electrical properties and nicotinic activation of prevertebral ganglion neurones were investigated in vitro on themale rat major pelvic ganglion and rabbit coeliac ganglion. The electricalactivity of the neurones was recorded using intracellular recording techniques. Nicotinic activation was triggered for neurones of the major pelvic ganglion by stimulating the hypogastric, pelvic and cavernous nerves and forcoeliac neurones by stimulating the splanchnic nerves. Testosterone modified the resting membrane potential of neurones in the major pelvic ganglion by triggering a slow depolarization, and was without significant effect on the resting membrane potential of coeliac ganglion neurones. In neurones ofthe major pelvic and coeliac ganglia, testosterone had no significant effect on the firing pattern, on the characteristics of the action potential (firing threshold, duration, overshoot) and on the after-hyperpolarization (amplitude and duration). Testosterone affected, in opposite ways, the nicotinic activation of neurones of the two prevertebral ganglia. In the major pelvic ganglion, testosterone triggered an increase in the amplitude of excitatory postsynaptic potentials induced by stimulation or the hypogastric, pelvic and cavernous nerves with a single pulse, revealing a facilitation of nicotinic activation. On coeliac ganglion neurones, testosterone elicited adecrease in the amplitude of excitatory postsynaptic potentials induced bystimulation of the splanchnic nerves, indicating an inhibition of nicotinic activation. Our study shows that testosterone acts differently on neurones of prevertebral ganglia involved in the nervous control of different functions, its facilitatory action being exerted on neurones df the major pelvic ganglion which is particularly involved in the control of the urogenital tract. Our study reinforces the concept, derived from neuroanatomical and pharmacological studies, of the major pelvic ganglion as a major peripheral target for testosterone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:45:14