Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Involvement of N-methyl-D-aspartic acid receptor activation in oxytocin and vasopressin release after osmotic stimuli in rats
Autore:
Onaka, T; Yagi, K;
Indirizzi:
Jichi Med Sch, Dept Physiol, Minami Kawachi, Tochigi 3290498, Japan Jichi Med Sch Minami Kawachi Tochigi Japan 3290498 Tochigi 3290498, Japan
Titolo Testata:
JOURNAL OF NEUROENDOCRINOLOGY
fascicolo: 2, volume: 13, anno: 2001,
pagine: 166 - 174
SICI:
0953-8194(200102)13:2<166:IONARA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-NMDA RECEPTORS; NEURONS IN-VITRO; NEUROENDOCRINE RESPONSES; NEUROSECRETORY-CELLS; SUPRAOPTIC NEURONS; EXPRESSION;
Keywords:
supraoptic nucleus; glutamate; NMDA receptor; cholecystokinin octapeptide; organum vasculosum of the lamina terminalis (OVLT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Onaka, T Jichi Med Sch, Dept Physiol, Minami Kawachi, Tochigi 3290498, Japan Jichi Med Sch Minami Kawachi Tochigi Japan 3290498 290498, Japan
Citazione:
T. Onaka e K. Yagi, "Involvement of N-methyl-D-aspartic acid receptor activation in oxytocin and vasopressin release after osmotic stimuli in rats", J NEUROENDO, 13(2), 2001, pp. 166-174

Abstract

The present study aimed to examine roles of N-methyl-D-aspartic acid (NMDA) receptors in oxytocin and vasopressin release after osmotic stimuli. A noncompetitive NMDA receptor antagonist, MK-801 (0.2 mg/kg body weight, i.p.), significantly decreased plasma concentrations of oxytocin and vasopressinafter hypertonic saline injection (0.3 or 0.6 M NaCl, i.p., 20 ml/kg). By contrast, oxytocin release induced by injection of cholecystokinin octapeptide (20 mug/kg, i.p,) was not significantly changed by MK-801. Hypertonic saline injection increased the number of cells expressing Fos in the supraoptic nucleus and in the regions anterior and ventral to the third ventricle (AV3V) regions [the organum vasculosum of the lamina terminalis (OVLT) and median preoptic nucleus]. MK-801 decreased the number of cells expressing protein in these areas after hypertonic saline injection. A microdialysis method showed that a hypertonic saline injection (0.6 M NaCl, 20 ml/kg, i.p.)facilitated glutamic acid release in and near the OVLT. The results support the view that NMDA receptor in the AV3V region modulates in a facilitative fashion the AV3V inputs to the supraoptic neurosecretory neurones.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:02:27