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Titolo:
Remnant lipoproteins are related to intima-media thickness of the carotid artery independently of LDL cholesterol and plasma triglycerides
Autore:
Karpe, F; Boquist, S; Tang, R; Bond, GM; de Faire, U; Hamsten, A;
Indirizzi:
King Gustaf V Res Inst, S-17176 Stockholm, Sweden King Gustaf V Res Inst Stockholm Sweden S-17176 -17176 Stockholm, Sweden Karolinska Inst, Dept Med, S-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17176 Med, S-17176 Stockholm, Sweden Radcliffe Infirm, Oxford Lipid Metab Grp, Oxford OX2 6HE, England Radcliffe Infirm Oxford England OX2 6HE tab Grp, Oxford OX2 6HE, England Univ Oxford, Nuffield Dept Clin Med, Oxford OX2 6HE, England Univ Oxford Oxford England OX2 6HE ept Clin Med, Oxford OX2 6HE, England Wake Forest Univ, Sch Med, Div Ultrasound Res, Winston Salem, NC 27109 USAWake Forest Univ Winston Salem NC USA 27109 , Winston Salem, NC 27109 USA Karolinska Inst, Div Cardiovasc Epidemiol, Stockholm, Sweden Karolinska Inst Stockholm Sweden ardiovasc Epidemiol, Stockholm, Sweden Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-10401 Med, S-10401 Stockholm, Sweden
Titolo Testata:
JOURNAL OF LIPID RESEARCH
fascicolo: 1, volume: 42, anno: 2001,
pagine: 17 - 21
SICI:
0022-2275(200101)42:1<17:RLARTI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
APO A-I; RICH LIPOPROTEINS; ALIMENTARY LIPEMIA; B-100; PARTICLES; MEN;
Keywords:
triglyceride-rich lipoproteins; vascular wall; alimentary lipemia; chylomicrons; very low density lipoproteins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Karpe, F Radcliffe Infirm, Oxford Lipid Metab Grp, Oxford OX2 6HE, EnglandRadcliffe Infirm Oxford England OX2 6HE Oxford OX2 6HE, England
Citazione:
F. Karpe et al., "Remnant lipoproteins are related to intima-media thickness of the carotid artery independently of LDL cholesterol and plasma triglycerides", J LIPID RES, 42(1), 2001, pp. 17-21

Abstract

Remnants of triglyceride-rich lipoproteins (TRL) have been implicated in the early development of atherosclerosis, We tested this hypothesis by quantifying the plasma concentration of remnant-like particle cholesterol (RLP-C) in a cohort of healthy 50-year-old men in whom the common carotid artery intima-media thickness (CCA-IMT) was assessed by B-mode ultrasound as a surrogate marker for atherosclerosis, The subjects were given a fat-rich meal to study the generation of RLP-C during postprandial lipemia, Fasting plasma RLP-C and other major fasting plasma lipids and lipoproteins were determined twice, and the mean RLP-C concentration was strongly correlated with CCA-IMT (r = 0.32, P = 0.002), In addition, low density lipoprotein (LDL) cholesterol (r = 0.25, P = 0.01) and plasma triglycerides (r 0.20, P = 0.05) were significantly related to CCA-IMT. Multivariate analyses showed a triglyceride-independent contribution of RLP-C to CCA-IMT. After fat intake, the median plasma RLP-C concentration was doubled after 3 h, The increase was strongly related to the postprandial generation of TRL apolipoprotein (apo)B-48, and large (S-f 60-400) TRL apoB-100, The association with CCA-IMT was somewhat stronger for the 3-h RLP-C level than for the fasting RLP-C concentration [r = 0.27, P < 0.01 (3 h) compared with r = 0.22, P < 0.05 (0 h)]. We conclude that the plasma concentration of RLP-C is related to CCA-IMT, independent of plasma triglycerides and LDL cholesterol, in a healthy middle-aged male population.

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Documento generato il 27/09/20 alle ore 13:38:01