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Titolo:
Platelet endothelial cell adhesion molecule-1 and vascular endothelial cadherin cooperatively regulate fibroblast growth factor-induced modulations of adherens junction functions
Autore:
Halama, T; Groger, M; Pillinger, M; Staffler, G; Prager, E; Stockinger, H; Holnthoner, W; Lechleitner, S; Wolff, K; Petzelbauer, P;
Indirizzi:
Univ Vienna, Sch Med, Dept Dermatol, Div Gen Dermatol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 v Gen Dermatol, A-1090 Vienna, Austria Univ Vienna, Sch Med, VIRCC, Inst Immunol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 , Inst Immunol, A-1090 Vienna, Austria
Titolo Testata:
JOURNAL OF INVESTIGATIVE DERMATOLOGY
fascicolo: 1, volume: 116, anno: 2001,
pagine: 110 - 117
SICI:
0022-202X(200101)116:1<110:PECAMA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE-PHOSPHATASE; BETA-CATENIN; VE-CADHERIN; DIFFERENTIAL ASSOCIATION; INTERCELLULAR-JUNCTIONS; SIGNAL-TRANSDUCTION; ACTIN CYTOSKELETON; FACTOR RECEPTOR; PECAM-1; COMPLEX;
Keywords:
actin; beta-catenin; CD31; CD144; transmigration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Petzelbauer, P Univ Vienna, Sch Med, Dept Dermatol, Div Gen Dermatol, Waehringer Guertel 18-20, A-1090 Vienna, Austria Univ Vienna Waehringer Guertel18-20 Vienna Austria A-1090
Citazione:
T. Halama et al., "Platelet endothelial cell adhesion molecule-1 and vascular endothelial cadherin cooperatively regulate fibroblast growth factor-induced modulations of adherens junction functions", J INVES DER, 116(1), 2001, pp. 110-117

Abstract

Cellular adherens junctions are formed by cadherins linked to proteins of the catenin family. In endothelial cells, not only vascular endothelial cadherin but also platelet endothelial cell adhesion molecule-1 localizes intojunctions and associates with beta -catenin, To explore a putative cooperation of platelet endothelial cell adhesion molecule-1 and vascular endothelial cadherin, we analyzed transfectants expressing either platelet endothelial cell adhesion (CD31 cells) or vascular endothelial cadherin (CD144 cells) or both molecules (CD31/CD144 cells), and, for comparison, human umbilical vein endothelial cells. Basic fibroblast growth factor completely dissociated vascular endothelial cadherin/beta -catenin complexes and robustly moved beta -catenin into the nucleus in CD144 cells, whereas in CD31/CD144 cells as well as in human umbilical vein endothelial cells, fibroblast growthfactor only partially dissociated the junctional complex followed by a significantly reduced nuclear translocation of beta -catenin, In contrast, in CD31 cells, the subcellular distribution of beta -catenin remained unaffected by fibroblast growth factor. As a functional consequence, fibroblast growth factor induced a complete collapse of the F-actin network in CD144 cells, a limited rearrangement of F-actin fibers in CD31/CD144 cells and no F-actin rearrangement in CD31 cells. We also analyzed the effect of fibroblastgrowth factor-induced rearrangement of junctions on junction permeability for leukocytes: in line with our observation that vascular endothelial cadherin was required for cells to respond to fibroblast growth factor, only inCD31/CD144 cells, but not in CD31 cells, leukocyte transmigration was significantly enhanced by fibroblast growth factor. In conclusion platelet endothelial cell adhesion molecule-1 cooperates with vascular endothelial cadherin in a mutual fashion; platelet endothelial cell adhesion molecule-1 reduces and temporarily limits fibroblast growth factor-induced dissociation ofvascular endothelial cadherin/beta -catenin complexes, but requires vascular endothelial cadherin to control leukocyte transmigration in dependence of fibroblast growth factor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:59:05