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Titolo:
Effects of oral L-arginine on plasma nitrate and blood pressure in cortisol-treated humans
Autore:
Kelly, JJ; Williamson, P; Martin, A; Whitworth, JA;
Indirizzi:
Univ New S Wales, St George Hosp, Dept Renal Med, Kogarah, NSW 2217, Australia Univ New S Wales Kogarah NSW Australia 2217 Kogarah, NSW 2217, Australia Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia Australian Natl Univ Canberra ACT Australia 2601 rra, ACT 2601, Australia
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 2, volume: 19, anno: 2001,
pagine: 263 - 268
SICI:
0263-6352(200102)19:2<263:EOOLOP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; ENDOTHELIUM-DEPENDENT DILATION; INDUCED HYPERTENSION; RENAL RESPONSE; GENERATION; INCREASES; CELLS;
Keywords:
cortisol; hypertension; nitric oxide; L-arginine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Kelly, JJ Univ New S Wales, St George Hosp, Dept Renal Med, Kogarah, NSW 2217, Australia Univ New S Wales Kogarah NSW Australia 2217 NSW 2217, Australia
Citazione:
J.J. Kelly et al., "Effects of oral L-arginine on plasma nitrate and blood pressure in cortisol-treated humans", J HYPERTENS, 19(2), 2001, pp. 263-268

Abstract

Objective The aim of this study was to determine whether cortisol-induced hypertension can be reversed by coadministration of oral L-arginine. Study design Three studies were undertaken in healthy male human subjects. The first study addressed the effect of oral L-arginine loading on plasma arginine concentration. Study 2 addressed the effect of coadministration ofcortisol with L-arginine on plasma L-arginine concentrations. Study 3 was a randomized placebo crossover control comparing the effects of cortisol 80mg/day co-administered with a placebo to cortisol 80 mg/day co-administered with L-arginine 21 g/day,Methods Blood pressure was measured by a random Hawksley sphygmomanometer. Plasma nitrate/nitrite concentrations were measured by a modified Greiss reaction. Plasma arginine and citrulline concentrations were measured by an automated amino acid analyser. Results Plasma arginine concentrations were doubled by oral doses of 15 g/day and 21 g/day of L-arginine (study 1). Go-administration of cortisol didnot alter plasma arginine concentrations in subjects taking 21 g of L-arginine per day (study 2). Go-administration of L-arginine 21 g/day with cortisol 80 mg/day did not prevent cortisol-induced increases in blood pressure or cortisol-induced falls in plasma nitrate/nitrite concentrations. Conclusion Cortisol-induced hypertension is accompanied by a fall in plasma nitrate/nitrite concentrations. Oral L-arginine administration does not prevent cortisol-induced falls in plasma nitrate/nitrite concentrations or increases in blood pressure. We propose that cortisol-induced reductions in nitrate/nitrite production occur at a point distal to L-arginine availability in the nitric oxide synthase pathway. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 10:57:24