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Titolo:
MHC class I gene expression and regulation
Autore:
Agrawal, S; Kishore, MC;
Indirizzi:
Sanjay Gandhi Postgrad Inst Med Sci, Dept Med Genet, Lucknow 226014, UttarPradesh, India Sanjay Gandhi Postgrad Inst Med Sci Lucknow Uttar Pradesh India 226014 ia Cleveland Clin Fdn, Lerner Res Inst, Dept Immunol, Cleveland, OH 44195 USACleveland Clin Fdn Cleveland OH USA 44195 mmunol, Cleveland, OH 44195 USA
Titolo Testata:
JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH
fascicolo: 6, volume: 9, anno: 2000,
pagine: 795 - 812
SICI:
1525-8165(200012)9:6<795:MCIGEA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR HISTOCOMPATIBILITY COMPLEX; HLA CLASS-I; NF-KAPPA-B; TAT REPRESSES TRANSCRIPTION; STIMULATED RESPONSE ELEMENT; ENHANCER-BINDING-PROTEIN; TRANSFORMED RAT-CELLS; TUMOR-NECROSIS-FACTOR; INTERFERON-GAMMA; DOWN-REGULATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
121
Recensione:
Indirizzi per estratti:
Indirizzo: Agrawal, S Sanjay Gandhi Postgrad Inst Med Sci, Dept Med Genet, Raebareli Rd, Lucknow226014, Uttar Pradesh, India Sanjay Gandhi Postgrad Inst Med SciRaebareli Rd Lucknow Uttar Pradesh India 226014
Citazione:
S. Agrawal e M.C. Kishore, "MHC class I gene expression and regulation", J HEMATH ST, 9(6), 2000, pp. 795-812

Abstract

Major histocompatibility complex (MHC) is a conglomerate of genes that play an important role in recognition of self and nonself, These genes are under tight control. In this review we have discussed the transcription processes regulating MHC gene expression. Various biological or chemical modulators can modulate MHC gene expression. The promoter region of class I genes can be activated through several pathways. Hence, these genes are not typical "domestic" genes. Extensive studies on regulation of MHC class I expression, using transfection techniques and transgenic animal models, have resulted in identification of various cis-acting sequences involved in positive and negative regulation of class I genes. Work is in progress to identify the transacting proteins that bind to these sites and to delineate the mechanisms that regulate constitutive and inducible expression of class I genes in normal and diseased cells. It has been seen that various biological molecules (IFN, GMCSF, IL-2) and other chemicals up-regulate the MHC expression. If the exact mechanisms are known by which the expression of class I genesis up regulated, the efforts can be made to balance the beneficial and toxic effects of biological molecules with one another, which may facilitate the use of combination of these molecules in subpharmacological doses (to eliminate toxicity) for early and better management of neoplastic diseases, as it is well-known that during malignancy MHC gene expression is down-regulated. In the future, the use of transgenic and knockout mice will be usefulin acquiring a better understanding, which may further help in cancer therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 09:42:25