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Titolo:
The molecular control of upper extremity development: Implications for congenital hand anomalies
Autore:
Daluiski, A; Yi, SE; Lyons, KM;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Dept Orthopaed Surg, Los Angeles, CA USA Univ Calif Los Angeles Los Angeles CA USA paed Surg, Los Angeles, CA USA Univ Calif Los Angeles, Sch Med, Dept Biol Chem, Los Angeles, CA USA Univ Calif Los Angeles Los Angeles CA USA Biol Chem, Los Angeles, CA USA Univ Calif Los Angeles, Sch Med, Dept Mol Cellular & Dev Biol, Los Angeles, CA USA Univ Calif Los Angeles Los Angeles CA USA Dev Biol, Los Angeles, CA USA
Titolo Testata:
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
fascicolo: 1, volume: 26A, anno: 2001,
pagine: 8 - 22
SICI:
0363-5023(200101)26A:1<8:TMCOUE>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SAETHRE-CHOTZEN-SYNDROME; APICAL ECTODERMAL RIDGE; VERTEBRATE LIMB DEVELOPMENT; POSITIVE FEEDBACK LOOP; PROGRAMMED CELL-DEATH; NAIL-PATELLA SYNDROME; HOLT-ORAM SYNDROME; SONIC-HEDGEHOG; CROUZON-SYNDROME; MUTANT MICE;
Keywords:
molecular biology; limb development;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
101
Recensione:
Indirizzi per estratti:
Indirizzo: Daluiski, A Hosp Special Surg, 535 E 70th St, New York, NY 10021 USA Hosp Special Surg 535 E 70th St New York NY USA 10021 0021 USA
Citazione:
A. Daluiski et al., "The molecular control of upper extremity development: Implications for congenital hand anomalies", J HAND S-AM, 26A(1), 2001, pp. 8-22

Abstract

As the molecular aspects of limb development are being unraveled, more of the congenital anomalies seen by hand surgeons in the clinical setting willhave an identifiable molecular basis. The majority of the data available regarding the molecular development of the upper extremity have come from experimental animal studies, specifically the mouse and chicken. These findings are being discovered by either direct surgical and molecular manipulation of the developing limb or by production of mice deficient in specific genes. Relatively few specific human mutations that cause limb abnormalities have been identified. Hand surgeons should be aware of the basic molecular pathways controlling limb development because they are in a unique position to be able to identify patients with such deformities. In turn, derailed clinical descriptions of congenital anomalies affecting the upper extremity will advance the understanding of the cellular events controlled by the molecular pathways of limb development. This review describes the general molecular basis of limb development and correlates it with disease processes affecting the upper extremity. (J Hand Surg 2001;26A:8-22. Copyright (C) 2001 by the American Society for Surgery of the Hand.).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:29:55