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Titolo:
NEUROPHYSIOLOGY OF CONVERGING SYNAPTIC INPUTS FROM THE RAT PREFRONTALCORTEX, AMYGDALA, MIDLINE THALAMUS, AND HIPPOCAMPAL-FORMATION ONTO SINGLE NEURONS OF THE CAUDATE PUTAMEN AND NUCLEUS-ACCUMBENS/
Autore:
FINCH DM;
Indirizzi:
UNIV CALIF LOS ANGELES,BRAIN RES INST,CTR HLTH SCI 73364,BOX 951761 LOS ANGELES CA 90095
Titolo Testata:
Hippocampus
fascicolo: 5, volume: 6, anno: 1996,
pagine: 495 - 512
SICI:
1050-9631(1996)6:5<495:NOCSIF>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHASEOLUS-VULGARIS LEUCOAGGLUTININ; VENTRAL STRIATUM; ENTORHINAL CORTEX; BASAL GANGLIA; TOPOGRAPHICAL ORGANIZATION; INTRACELLULAR RESPONSES; EFFERENT CONNECTIONS; FIRING PATTERNS; SPINY NEURONS; GUINEA-PIG;
Keywords:
ENTORHINAL CORTEX; SUBICULUM; STRIATUM; INFRALIMBIC; PRELIMBIC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
88
Recensione:
Indirizzi per estratti:
Citazione:
D.M. Finch, "NEUROPHYSIOLOGY OF CONVERGING SYNAPTIC INPUTS FROM THE RAT PREFRONTALCORTEX, AMYGDALA, MIDLINE THALAMUS, AND HIPPOCAMPAL-FORMATION ONTO SINGLE NEURONS OF THE CAUDATE PUTAMEN AND NUCLEUS-ACCUMBENS/", Hippocampus, 6(5), 1996, pp. 495-512

Abstract

Neurophysiological responses mediated by projections from five telencephalic and diencephalic regions (the infra- and prelimbic portions ofthe prefrontal cortex, amygdala, midline and intralaminar thalamic nuclei, entorhinal cortex and subiculum/CA1) to the caudate/putamen (Cpu) and nucleus accumbens (Acb) of the dorsal and ventral striatum were studied in chloral-hydrate-anesthetized rats. Both extra- and intracellular in vivo recording techniques were used. A retrograde tracer (wheatgerm agglutinin-apo-horseradish peroxidase-5 nm colloidal Gold) was deposited in some animals in the vicinity of recording sites to confirm that stimulating electrodes were located near cells that projected to the striatum. Electrical stimulation of these five regions, respectively, evoked excitatory responses in 60%, 22%, 51%, 25%, and 17% of striatal neurons. Some responses, particularly with thalamic stimulation, showed short-term frequency potentiation in which 5/s stimulation increased the probability of spike firing. About half of responsive cells showed convergent excitation to more than one stimulating site. It was possible with convergent excitatory responses to show synaptic interactions: simultaneous activation of more than one site produced spatial and temporal summation to increase the probability of spike firing. Up to 5-way convergence onto single striatal neurons and up to 3-way interactions could be shown. These results indicate that functional influences from the hippocampal formation can converge with other excitatory input onto single striatal neurons to effect synaptic integration. (C) 1996 Wiley-Liss, Inc.

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Documento generato il 22/01/20 alle ore 06:36:53