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Titolo:
Cyclin-dependent kinase inhibitors, p21(waf1/cip1) and p27(kip1), are expressed site- and hair cycle-dependently in rat hair follicles
Autore:
Mitsui, S; Ohuchi, A; Adachi-Yamada, T; Hotta, M; Tsuboi, R; Ogawa, H;
Indirizzi:
Kyoto Prefectural Univ Med, Dept Cell Biol, Res Inst Neuronal Dis & Geriatr, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kyoto Japan 6028566 atr, Kyoto 6028566, Japan Kao Biol Sci Labs, Haga, Tochigi, Japan Kao Biol Sci Labs Haga Tochigi Japan Biol Sci Labs, Haga, Tochigi, Japan Nagoya Univ, Fac Sci, Chikusa Ku, Nagoya, Aichi 46401, Japan Nagoya Univ Nagoya Aichi Japan 46401 ikusa Ku, Nagoya, Aichi 46401, Japan Juntendo Univ, Sch Med, Dept Dermatol, Bunkyo Ku, Tokyo 1138421, Japan Juntendo Univ Tokyo Japan 1138421 matol, Bunkyo Ku, Tokyo 1138421, Japan
Titolo Testata:
JOURNAL OF DERMATOLOGICAL SCIENCE
fascicolo: 2, volume: 25, anno: 2001,
pagine: 164 - 169
SICI:
0923-1811(200102)25:2<164:CKIPAP>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICE LACKING; GENE-EXPRESSION; GROWTH-FACTORS; DIFFERENTIATION; P21; CELLS; KERATINOCYTES; HYPERPLASIA; EPIDERMIS; PROTEIN;
Keywords:
cyclin-dependent kinase inhibitor; p21; p27; hair cycle; high sulfur protein; hair keratin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Mitsui, S Kyoto Prefectural Univ Med, Dept Cell Biol, Res Inst Neuronal Dis & Geriatr, Kamigyo Ku, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kamigyo Ku Kyoto Japan 6028566 Japan
Citazione:
S. Mitsui et al., "Cyclin-dependent kinase inhibitors, p21(waf1/cip1) and p27(kip1), are expressed site- and hair cycle-dependently in rat hair follicles", J DERMA SCI, 25(2), 2001, pp. 164-169

Abstract

In order to investigate the role of cyclin-dependent kinase (CDK) inhibitors in hair growth, we analyzed the expressions of p21(wafl/cip1) and p27(kip1) during the synchronized hair cycle of rat coat. The mRNAs of both p21(waf1/cip1) and p27(kip1) were detected in anagen hair follicles by reverse transcription and polymerase chain reaction and their localization was clearly demonstrated in the upper half portion of the hair bulb and the cortex by in situ hybridization. The dermal tissue containing hair follicles was then excised from the anterior dorsal skin of the 5-12-week-old rats at 0.5 week intervals and the expressions of p21(wafl/cip1) and p27(kip1) were analyzed by northern blot hybridization. The mRNA of both CDK inhibitors was expressed at relatively high levels during anagen than during telogen, a factwhich correlated with the mRNA expression levels of hair differentiation markers, type I hair keratin (Ha3) and high sulfur protein B2. These resultsimply that CDK inhibitors, p21(wafl/cip1) and p27(kip1), are involved in the differentiation of follicular epithelial cells. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 00:00:07