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Titolo:
Electron-capture gas chromatographic-chemical ionization mass spectrometric study of sera from people vaccinated with bacille Calmette-Guerin for characteristic metabolites
Autore:
Syriopoulou, V; Brooks, JB; Daikos, GL;
Indirizzi:
Aghia Sophia Childrens Hosp, Dept Pediat 1, Athens 11527, Greece Aghia Sophia Childrens Hosp Athens Greece 11527 1, Athens 11527, Greece Natl Ctr Infect Dis, Div AIDS STD & TB Lab Res, Atlanta, GA 30333 USA NatlCtr Infect Dis Atlanta GA USA 30333 B Lab Res, Atlanta, GA 30333 USA Sismanogl Gen Hosp, Athens 15126, Greece Sismanogl Gen Hosp Athens Greece 15126 gl Gen Hosp, Athens 15126, Greece
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1, volume: 751, anno: 2001,
pagine: 143 - 151
SICI:
1387-2273(20010210)751:1<143:EGCIMS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUBERCULOSTEARIC ACID; LIQUID-CHROMATOGRAPHY; CEREBROSPINAL-FLUID;
Keywords:
bacille Calmette-Guerin; tuberculostearic acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Syriopoulou, V Aghia Sophia Childrens Hosp, Dept Pediat 1, Thivon & Livadias St, Athens 11527, Greece Aghia Sophia Childrens Hosp Thivon & Livadias St Athens Greece 11527
Citazione:
V. Syriopoulou et al., "Electron-capture gas chromatographic-chemical ionization mass spectrometric study of sera from people vaccinated with bacille Calmette-Guerin for characteristic metabolites", J CHROMAT B, 751(1), 2001, pp. 143-151

Abstract

Serum samples from 26 individuals vaccinated with bacille Calmette-Guerin (BCG) and from 26 controls (10 patients with pulmonary tuberculosis and 16 non BCG-vaccinated healthy individuals) were analyzed by frequency-pulsed electron-capture gas chromatography (FPEC-GC) and chemical ionization gas chromatography-mass spectrometry (CIGC-MS) for the presence of characteristicmetabolites. A distinct pattern consisted of tuberculostearic acid (TSA) and a peak, labeled peak 1, was observed in all BCG-vaccinated individuals, whereas only three of 26 controls generated this chromatography profile. TSA was detected in all patients with pulmonary tuberculosis but peak 1 was absent. Sera drawn from 12 individuals 11 to 14 days after BCG vaccination yielded three transitional FPEC-GC profiles. A permanent FPEC-GC profile consisting of TSA and of a full scale peak 1 appeared 28 days to a few months after BCG vaccination. Peak 1 was tentatively identified by CIGC-MS as 9-methyl-hexacosanol. The findings suggest that peak 1 may serve as a marker todetect Mycobacterium bovis BCG and to distinguish individuals infected with M. tuberculosis from individuals vaccinated with BCG. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 05/04/20 alle ore 19:42:04