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Titolo:
Fluorescence-enhanced absorption imaging using frequency-domain photon migration: tolerance to measurement error
Autore:
Lee, J; Sevick-Muraca, E;
Indirizzi:
Texas A&M Univ, Sch Chem Engn, College Stn, TX 77843 USA Texas A&M Univ College Stn TX USA 77843 m Engn, College Stn, TX 77843 USA Purdue Univ, Sch Elect & Comp Engn, W Lafayette, IN 47907 USA Purdue UnivW Lafayette IN USA 47907 Comp Engn, W Lafayette, IN 47907 USA
Titolo Testata:
JOURNAL OF BIOMEDICAL OPTICS
fascicolo: 1, volume: 6, anno: 2001,
pagine: 58 - 67
SICI:
1083-3668(200101)6:1<58:FAIUFP>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPTICAL TOMOGRAPHY; BOUNDARY-CONDITIONS; TURBID MEDIA; IN-VIVO; SCATTERING; TISSUE;
Keywords:
photon migration imaging; biomedical optical imaging; fluorescent contrast agents; image reconstruction algorithms; measurement noise;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Engineering, Computing & Technology
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Sevick-Muraca, E Texas A&M Univ, Sch Chem Engn, College Stn, TX 77843 USA Texas A&M Univ College Stn TX USA 77843 tn, TX 77843 USA
Citazione:
J. Lee e E. Sevick-Muraca, "Fluorescence-enhanced absorption imaging using frequency-domain photon migration: tolerance to measurement error", J BIOMED OP, 6(1), 2001, pp. 58-67

Abstract

Enhanced contrast of frequency-domain photon migration (FDPM) measurementsfor successful biomedical optical imaging may be theoretically achieved with exogenous fluorescence contrast agents. However in practice, the reducedfluorescence signals detected at the air-tissue interface possess significant noise when compared to the signals collected at the incident wavelength. In this study, we experimentally assess signal to noise ratios (SNRs) forFDPM measurements in homogeneous tissue-like scattering media which absorband fluorescence. At 100 MHz, the SNR for our single-pixel FDPM signals atthe incident wavelength is approximately constant at 55 dB while the corresponding fluorescence signal SNR is variable with signal power and is approximately 35 dB. Using these SNR values to guide our studies on the tolerance of absorption and fluorescence-enhanced absorption imaging, we show that the noise tolerance of a Born iterative method far reconstruction of absorption from FDPM measurements at the incident wavelength cannot handle the reduced SNR that is tolerated by a Born iterative type approach for reconstruction of absorption from measurements at the emission wavelength. (C) 2001 Society of Photo-Optical Instrumentation Engineers.

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Documento generato il 23/01/20 alle ore 04:06:11