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Titolo:
Evaluation of a reproductive toxicity assay using Xenopus laevis: Boric acid, cadmium and ethylene glycol monomethyl ether
Autore:
Fort, DJ; Stover, EL; Bantle, JA; Dumont, JN; Finch, FA;
Indirizzi:
Stover Grp, Stillwater, OK 74074 USA Stover Grp Stillwater OK USA 74074Stover Grp, Stillwater, OK 74074 USA Oklahoma State Univ, Dept Zool, Stillwater, OK 74078 USA Oklahoma State Univ Stillwater OK USA 74078 ool, Stillwater, OK 74078 USA USA, Ctr Environm Hlth Res, Ft Detrick, MD 21702 USA USA Ft Detrick MD USA 21702 r Environm Hlth Res, Ft Detrick, MD 21702 USA
Titolo Testata:
JOURNAL OF APPLIED TOXICOLOGY
fascicolo: 1, volume: 21, anno: 2001,
pagine: 41 - 52
SICI:
0260-437X(200101/02)21:1<41:EOARTA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMBRYO TERATOGENESIS ASSAY; METABOLIC-ACTIVATION SYSTEM; OOCYTES IN-VITRO; DEVELOPMENTAL TOXICITY; ATLANTIC CROAKER; MATURATION; FETAX; RATS; MICE; CONTAMINANTS;
Keywords:
Xenopus; reproductive toxicity assay; cadmium; boric acid; ethylene glycol monomethyl ether; transgenerational toxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Fort, DJ Ft Environm Labs, 1414 S Sangre Rd, Stillwater, OK 74074 USA Ft Environm Labs 1414 S Sangre Rd Stillwater OK USA 74074 074 USA
Citazione:
D.J. Fort et al., "Evaluation of a reproductive toxicity assay using Xenopus laevis: Boric acid, cadmium and ethylene glycol monomethyl ether", J APPL TOX, 21(1), 2001, pp. 41-52

Abstract

Cadmium (Cd), boric acid (BA) and ethylene glycol monomethyl ether (EGME) were evaluated for reproductive and developmental toxicity in Xenopus laevis. Eight reproductively mature adult male and eight superovulated female Xenopus laevis were exposed to at least five separate sublethal concentrations of each material via the culture water for a period of 30 days. Four respective pairs were mated and the offspring evaluated for developmental effects; an evaluation of reproductive status was performed on the remaining four specimens. Ovary pathology, oocyte count, oocyte maturity and maturation capacity (germinal vesicle breakdown, GVBD) and necrosis were evaluated in the female, whereas testis pathology, sperm count, dysmorphology and motility were studied in the male. Based on this assessment, each test material exerted reproductive toxicity in Xenopus laevis, but with varying potencies. Adult female exposure to Cd and EGME particularly, and to a lesser extent to BA, resulted in transgenerational toxicity to the developing progeny. Further, this model appears to be a useful tool in the initial assessment andprioritization of potential reproductive toxicants for further testing. Copyright (C) 2001 John Wiley & Sons, Ltd.

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Documento generato il 07/04/20 alle ore 22:30:01