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Titolo:
Prevention of hepatic and peritoneal metastases by the angiogenesis inhibitor FR-118487 after removal of growing tumor in mice
Autore:
Tanaka, T; Konno, H; Baba, S; Kanai, T; Matsumoto, K; Matsuda, I; Ohba, K; Ohta, M; Kamiya, K; Nakamura, S;
Indirizzi:
Hamamatsu Univ, Sch Med, Dept Surg 2, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 4313192 , Shizuoka 4313192, Japan
Titolo Testata:
JAPANESE JOURNAL OF CANCER RESEARCH
fascicolo: 1, volume: 92, anno: 2001,
pagine: 88 - 94
SICI:
0910-5050(200101)92:1<88:POHAPM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; HUMAN COLON-CANCER; LIVER METASTASIS; VASCULAR-PERMEABILITY; TNP-470; APOPTOSIS; TUMORIGENESIS; SUPPRESSION; ANGIOSTATIN; ANTIBODY;
Keywords:
hepatic metastasis; metastasis after surgery; human colon cancer; angiogenesis inhibitor; tumor removal;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Tanaka, T Hamamatsu Univ, Sch Med, Dept Surg 2, 3600 Handa Cho, Hamamatsu,Shizuoka 4313192, Japan Hamamatsu Univ 3600 Handa Cho Hamamatsu Shizuoka Japan 4313192 n
Citazione:
T. Tanaka et al., "Prevention of hepatic and peritoneal metastases by the angiogenesis inhibitor FR-118487 after removal of growing tumor in mice", JPN J CANC, 92(1), 2001, pp. 88-94

Abstract

We established a mouse "primary tumor resection model" in which a transplanted tumor was resected after an orthotopic transplantation of colorectal cancer tissue to estimate the therapeutic effect of an angiogenesis inhibitor on metastasis, The angiogenesis inhibitor FR-118487 is a member of the fumagillin family. Here, I mg/kg/day of FR-118487 was subcutaneously administered to nude mice for 1 week, 2 weeks, or 4 weeks through an osmotic pump. Liver metastasis developed in 7 of 9 control mice, 2 of 6 mice that underwent the tumor resection 2 weeks after transplantation (early resection), andin all 7 of the mice that underwent the tumor resection 4 weeks after transplantation (late resection), In the short treatment trial, the FR-118487 administration immediately after the early resection completely inhibited both hepatic and peritoneal metastases, whereas its administration after the late resection had no effect on liver metastasis, In the prolonged treatment trial, inhibitory effects of prolonged treatment with FR-118487 on both hepatic and peritoneal metastases after the late resection were clearly demonstrated. The mice of the resection-alone group all died within 106 days after tumor inoculation, due to metastases of colon carcinoma. In contrast, half of the mice that underwent resection and then received antiangiogenic therapy were alive at the end of the observation period (160 days after transplantation). In conclusion, the combination of surgery and subsequent antiangiogenic therapy may be useful to prevent the distant metastasis of colorectal cancer and to improve the prognosis of patients with colorectal cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:58:22