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Titolo:
Life style and urinary 8-hydroxydleoxyguanosine, a marker of oxidative DNAdamage: Effects of exercise, working conditions, meat intake, body mass index, and smoking
Autore:
Kasai, H; Iwamoto-Tanaka, N; Miyamoto, T; Kawanami, K; Kawanami, S; Kido, R; Ikeda, M;
Indirizzi:
Univ Occupat & Environm Hlth, Inst Ind Ecol Sci, Dept Environm Oncol, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 8555, Japan Univ Occupat & Environm Hlth, Inst Ind Ecol Sci, Dept Occupat Hlth Econ, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 8555, Japan Nippon Steel Corp Ltd, Tech Dev Bur, Kimitsu 2991141, Japan Nippon Steel Corp Ltd Kimitsu Japan 2991141 Bur, Kimitsu 2991141, Japan
Titolo Testata:
JAPANESE JOURNAL OF CANCER RESEARCH
fascicolo: 1, volume: 92, anno: 2001,
pagine: 9 - 15
SICI:
0910-5050(200101)92:1<9:LSAU8A>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIQUID-CHROMATOGRAPHY; 8-HYDROXYDEOXYGUANOSINE; 8-HYDROXY-2'-DEOXYGUANOSINE; 8-HYDROXYGUANINE; SPECTROMETRY; EXCRETION; RADICALS; SITE; LUNG;
Keywords:
8-hydroxydeoxyguanosine; exercise; meat intake; BMI; smoking;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Kasai, H Univ Occupat & Environm Hlth, Inst Ind Ecol Sci, Dept Environm Oncol, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 an
Citazione:
H. Kasai et al., "Life style and urinary 8-hydroxydleoxyguanosine, a marker of oxidative DNAdamage: Effects of exercise, working conditions, meat intake, body mass index, and smoking", JPN J CANC, 92(1), 2001, pp. 9-15

Abstract

The urinary levels of 8-hydroxydeoxyguanosine (8-OH-dG), a marker of oxidative DNA damage, of 318 healthy men aged 18-58 were measured with high resolution by a newly developed automated high-pressure liquid chromatography (HPLC) system coupled to an electrochemical detector (ECD). The mean 8-OH-dGlevel (mug/g creatinine) was 4.12+/-1.73 (SD). An eleven-fold inter-individual variation was observed. The accuracy of the measurement estimated fromthe recovery of an added 8-OH-dG standard was 90-98%. By univariate analysis, it was found that moderate physical exercise (P=0.0023) and high body mass index (BMI) (P=0.0032) reduced the 8-OH-dG level, while physical labor (P=0.0097), smoking (P=0.032), and low meat intake (less than once/week) (P=0.041) increased its level. Based on a multi-regression analysis of the log-transformed values, moderate physical exercise (P=0.0039), high BMI (P=0.0099), and age (P=0.021) showed significant reducing effects on the 8-OH-dGlevel, while low meat intake (P=0.010), smoking (P=0.013), and day-night shift work (P=0.044) increased its level. These results suggest that many types of life-style factors that either generate or scavenge oxygen radicals may affect the level of oxidative DNA damage of each individual.

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Documento generato il 25/11/20 alle ore 17:41:30