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Titolo:
Modulation of cell cycle-related protein expression by sodium butyrate in human non-small cell lung cancer cell lines
Autore:
Pellizzaro, C; Coradini, D; Daniotti, A; Abolafio, G; Daidone, MG;
Indirizzi:
Ist Nazl Studio & Cura Tumori, Dept Expt Oncol, Determinants Prognosis & Treatment Response Unit, I-20133 Milan, Italy Ist Nazl Studio & Cura TumoriMilan Italy I-20133 , I-20133 Milan, Italy
Titolo Testata:
INTERNATIONAL JOURNAL OF CANCER
fascicolo: 5, volume: 91, anno: 2001,
pagine: 654 - 657
SICI:
0020-7136(20010301)91:5<654:MOCCPE>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGNOSTIC FACTOR; WAF1/CIP1 GENE; IN-VITRO; GROWTH; CARCINOMA; DIFFERENTIATION; APOPTOSIS; ACID; INHIBITION; LEUKEMIA;
Keywords:
sodium butyrate; cell cycle-related proteins; lung cancer cell lines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Coradini, D Ist Nazl Tumori, Via Venezian 1, I-20133 Milan, Italy Ist NazlTumori Via Venezian 1 Milan Italy I-20133 lan, Italy
Citazione:
C. Pellizzaro et al., "Modulation of cell cycle-related protein expression by sodium butyrate in human non-small cell lung cancer cell lines", INT J CANC, 91(5), 2001, pp. 654-657

Abstract

To elucidate the mechanism of action of sodium butyrate (NaB), we examinedits effect on the expression of some cell cycle-related proteins (cyclins DI and E, p16(ink)4 p21(waf1) p27(Kip1)) in 2 human non-small cell lung cancer cell lines (NCI-460 and NCI-H23) characterized by wild- type and mutantTP53, respectively. The growth of both cell lines was inhibited in a dose-dependent manner and this process was accompanied by a modulation of cell cycle-related proteins. In NCI-H460, the p27(kip1) and p16(ink4) protein levels were markedly increased following NaB treatment, whereas p25(waf1) was only slightly elevated, with a peak at 2 mM NaB, and p53 was unaffected by any concentration. By contrast, in NCI-H23, a marked increase in p21(waf1) protein was paralleled by decreased p53 levels, whereas all the other investigated proteins remained stable. The results suggest that NaB blocks the growth of both cell lines by induction of cyclin-dependent kinase inhibitorstin particular, p25(waf1) in NCI-H23 and p27(kip1) and p16(ink4) in NCI-H460) through a p53-dependent or p53-independent mechanism, and open up interesting perspectives for the use of NaB as an alternative or additional strategy in the treatment of non-small cell lung carcinoma. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 07:46:50