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Titolo:
Enhancement of anti-tumor immunity by tumor cells transfected with the secondary lymphoid tissue chemokine EBI-1-ligand chemokine and stromal cell-derived factor-1 alpha chemokine genes
Autore:
Nomura, T; Hasegawa, H; Kohno, M; Sasaki, M; Fujita, S;
Indirizzi:
Ehime Univ, Sch Med, Dept Internal Med 1, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 Shigenobu, Ehime 7910295, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF CANCER
fascicolo: 5, volume: 91, anno: 2001,
pagine: 597 - 606
SICI:
0020-7136(20010301)91:5<597:EOAIBT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; MATURE DENDRITIC CELLS; CD8+ T-CELLS; IN-VIVO; MOLECULAR-CLONING; ANTITUMOR IMMUNITY; TRANSMEMBRANE-4 SUPERFAMILY; REDUCED TUMORIGENICITY; DISTINCT CHEMOKINES; BETA-CHEMOKINE;
Keywords:
chemokines; cancer immunotherapy; gene therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Hasegawa, H Ehime Univ, Sch Med, Dept Internal Med 1, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 Ehime 7910295, Japan
Citazione:
T. Nomura et al., "Enhancement of anti-tumor immunity by tumor cells transfected with the secondary lymphoid tissue chemokine EBI-1-ligand chemokine and stromal cell-derived factor-1 alpha chemokine genes", INT J CANC, 91(5), 2001, pp. 597-606

Abstract

Several new lymphocyte-specific chemokines, which attract naive and memoryT cells, B cells, dendritic cells and natural killer cells, have been isolated. We have found evidence of the anti-tumor effects of 3 major lymphocyte-specific chemokines, secondary lymphoid tissue chemokine (SLC), EBI-I-ligand chemokine (ELC) and stromal cell-derived factor (SDF)-1 alpha, in murine models (Meth A fibrosarcoma and HM-I ovarian tumor). In both naive and immunized mice, tumors expressing SLC, ELC or SDF-I alpha showed delayed progression compared with control tumors. In mice immunized with tumor cells expressing I of these 3 chemokine genes, challenge with parental tumor cells resulted in slightly slower progression than in control mice, while in miceImmunized with tumor cells transfected to co-express IL-2 or granulocyte-macrophage colony-stimulating factor (GM-CSF) as well as these chemokines, all tumors regressed. Furthermore, spleen cells from mice immunized with these "double-transfected" tumor cells exhibited higher proliferative responses and greater cytotoxic activity against parental tumor cells. These anti-tumor effects were associated with profound alterations in the leukocyte populations within the tumors and regional lymph nodes, and this was due to activation of type I T cell-dependent responses that produced high levels of IFN-gamma. These findings show that SLC, ELC and SDF-I alpha enhance anti-tumor immunity both systemically and locally and that these chemokines may be clinically useful, especially when combined with IL-2 and GM-CSF. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 00:24:01