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Titolo:
Signaling events following chemokine receptor ligation in human dendritic cells at different developmental stages
Autore:
Sato, K; Kawasaki, H; Nagayama, H; Enomoto, M; Morimoto, C; Tadokoro, K; Juji, T; Takahashi, TA;
Indirizzi:
Univ Tokyo, Inst Med Sci, Dept Cell Proc, Minato Ku, Tokyo 1088639, Japan Univ Tokyo Tokyo Japan 1088639 ell Proc, Minato Ku, Tokyo 1088639, Japan Univ Tokyo, Inst Med Sci, Dept Clin Immunol, Minato Ku, Tokyo 1088639, Japan Univ Tokyo Tokyo Japan 1088639 Immunol, Minato Ku, Tokyo 1088639, Japan Univ Tokyo, Inst Med Sci, AIDS Res Ctr, Minato Ku, Tokyo 1088639, Japan Univ Tokyo Tokyo Japan 1088639 Res Ctr, Minato Ku, Tokyo 1088639, Japan Japanese Red Cross, Cent Blood Ctr, Shibuya Ku, Tokyo 1501211, Japan Japanese Red Cross Tokyo Japan 1501211 Shibuya Ku, Tokyo 1501211, Japan
Titolo Testata:
INTERNATIONAL IMMUNOLOGY
fascicolo: 2, volume: 13, anno: 2001,
pagine: 167 - 179
SICI:
0953-8178(200102)13:2<167:SEFCRL>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-COUPLED RECEPTORS; N-TERMINAL KINASE; ALPHA-INDUCED ACTIVATION; TNF-ALPHA; T-CELLS; FUNCTIONAL EXPRESSION; DISTINCT CHEMOKINES; LANGERHANS CELLS; HUMAN BLOOD; MATURATION;
Keywords:
chemotaxis; protein tyrosine kinase; signal transduction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Takahashi, TA Univ Tokyo, Inst Med Sci, Dept Cell Proc, Minato Ku, 4-6-1 Shirokanedai, Tokyo 1088639, Japan Univ Tokyo 4-6-1 Shirokanedai Tokyo Japan 1088639 39, Japan
Citazione:
K. Sato et al., "Signaling events following chemokine receptor ligation in human dendritic cells at different developmental stages", INT IMMUNOL, 13(2), 2001, pp. 167-179

Abstract

Responsiveness of dendritic cells (DC) to inflammatory CC chemokines is down-regulated during their maturation. We analyzed the mechanism underlying these events. Cell-surface expression of CC chemokine receptor (CCR)-1, -3 and -5 was increased during differentiation of immature DC (IDC) from monocytes, In contrast, these expressions were decreased during development of IDC into mature DC (mDC) to levels similar to those of monocytes, Transcriptional expression of CCR-1, -3 and -5 was increased during differentiation of iDC from monocytes, while the expression was decreased during developmentof iDC into mDC, Expression of CCR-7 transcript was detected in mDC, but not in monocytes or iDC, Both monocytes and iDC, but not mDC, migrated in response to inflammatory CC chemokines such as regulated on activation normalT cell expressed and secreted (RANTES)/CCL5, whereas mDC, but not monocytes or IDC, migrated to macrophage inflammatory protein (MIP)-3 beta /CCL19. Receptor engagement of monocytes or iDC by RANTES (for CCR-1, -3 and -5) resulted in protein tyrosine phosphorylation events including activation of focal adhesion kinase as well as mitogen-activated protein kinase, whereas this stimulation induced little activation of these molecular events in mDC when compared with monocytes or iDC. On the other hand, stimulation with MIP-3 beta (for CCR-7) induced tyrosine phosphorylation events in mDC, but not in monocytes or IDC, These results suggest that the down-regulation of cell-surface expression of CCR and of their downstream signaling events may be involved in the reduced chemotaxis of DC to inflammatory CC chemokines during their maturation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:31:25