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Titolo:
Oral beta-stimulants can inhibit passive cutaneous anaphylaxis in rats through an indirect inhibitory mechanism: possible involvement of afferent andefferent nervous system via gastric beta(2)-adrenoceptor stimulation
Autore:
Shibata, H; Minami, E; Hirata, R; Nabe, T; Kohno, S;
Indirizzi:
Kyoto Pharmaceut Univ, Dept Pharmacol, Kyoto 6078414, Japan Kyoto Pharmaceut Univ Kyoto Japan 6078414 harmacol, Kyoto 6078414, Japan Kotaro Pharmaceut Co Ltd, Cent Res Lab, Takatsuki, Osaka 5690022, Japan Kotaro Pharmaceut Co Ltd Takatsuki Osaka Japan 5690022 aka 5690022, Japan
Titolo Testata:
INFLAMMATION RESEARCH
fascicolo: 12, volume: 49, anno: 2000,
pagine: 714 - 719
SICI:
1023-3830(200012)49:12<714:OBCIPC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SLOW REACTING SUBSTANCE; ADRENOCEPTOR ANTAGONISTS; PHENTOLAMINE; HISTAMINE; RELEASE; CELLS;
Keywords:
ephedrine; stomach; passive cutaneous anaphylaxis; adrenergic nerve; adrenoceptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Kohno, S Kyoto Pharmaceut Univ, Dept Pharmacol, Kyoto 6078414, Japan KyotoPharmaceut Univ Kyoto Japan 6078414 Kyoto 6078414, Japan
Citazione:
H. Shibata et al., "Oral beta-stimulants can inhibit passive cutaneous anaphylaxis in rats through an indirect inhibitory mechanism: possible involvement of afferent andefferent nervous system via gastric beta(2)-adrenoceptor stimulation", INFLAMM RES, 49(12), 2000, pp. 714-719

Abstract

Objective and Design: We previously demonstrated that oral l-ephedrine exerts an extremely rapid (within 20 s) inhibition of 48-h passive cutaneous anaphylaxis reaction (PCA) in rats by a possibly unidentified mode of action. In the present experiments, we elucidated the mechanism of the PCA inhibition by l-ephedrine using adrenoceptor agonists and antagonists. Materials: Rat antiserum was prepared with dinitrophenylated Ascaris suum extract + Bordetella pertussis. Treatment: Passively skin-sensitised Wistar rats were mainly used. l-ephedrine, and adrenoceptor agonists and antagonists were orally administered immediately before PCA provocation. Catecholamine depleting (6-hydroxydopamine, 6-OHDA), amine depleting (reserpine) or ganglion blocking (hexamethonium) agent was intraperitoneally or intravenously administered before the provocation. Methods: The effects of the drugs on PCA were assessed by inhibition of the dye leakage. Results: beta-(propranolol) and beta (2)-(butoxamine) blocking agents reduced the inhibition of PCA by l-ephedrine, while the inhibition was not altered by either an alpha -blocking agent (phentolamine) or a beta (1)-(atenolol) selective antagonist. On the other hand, beta-(isoproterenol) and beta (2)-selective (salbutamol) agonists showed extremely rapid inhibition of PCA. However, the Pi-selective agonist (dobutamine) had no effect on the reaction. The pretreatment with hexamethonium, reserpine or 6-OH-DA substantially attenuated the inhibitory effect of l-ephedrine on PCA. Conclusions: The results strongly suggest that beta (2)-adrenoceptors locate in the stomach and that their receptor excitement finally may lead to the inhibition of PCA via the stimulation of the central and peripheral nervous systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 08:01:26