Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Characterization of the MHC class I region of the Japanese pufferfish (Fugu rubripes)
Autore:
Clark, MS; Shaw, L; Kelly, A; Snell, P; Elgar, G;
Indirizzi:
HGMP Resource Ctr, Fugu Genom, Cambridge CB10 1SB, England HGMP Resource Ctr Cambridge England CB10 1SB Cambridge CB10 1SB, England Addenbrookes Hosp, Dept Med, Cambridge CB2 2QQ, England Addenbrookes HospCambridge England CB2 2QQ , Cambridge CB2 2QQ, England
Titolo Testata:
IMMUNOGENETICS
fascicolo: 3-4, volume: 52, anno: 2001,
pagine: 174 - 185
SICI:
0093-7711(2001)52:3-4<174:COTMCI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR HISTOCOMPATIBILITY COMPLEX; VERTEBRATE GENOME EVOLUTION; CARP CYPRINUS-CARPIO; PROTEASOME SUBUNIT; MOLECULAR-CLONING; RAINBOW-TROUT; CHROMOSOMAL LOCALIZATION; ONCORHYNCHUS-MYKISS; SEQUENCE ALIGNMENT; GENE ORGANIZATION;
Keywords:
Fugu; MHC; evolution; linkage; class I;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
80
Recensione:
Indirizzi per estratti:
Indirizzo: Clark, MS HGMP Resource Ctr, Fugu Genom, Wellcome Genome Campus, CambridgeCB10 1SB,England HGMP Resource Ctr Wellcome Genome Campus Cambridge England CB10 1SB
Citazione:
M.S. Clark et al., "Characterization of the MHC class I region of the Japanese pufferfish (Fugu rubripes)", IMMUNOGENET, 52(3-4), 2001, pp. 174-185

Abstract

A BAC map of the Japanese pufferfish (Fugu) MHC class I region was constructed using a mixture of sequence scanning and sequence-tagged site mapping methodologies. The Fugu MHC class Ia genes are linked to genes which are found within the human classical MHC class II and extended class II regions, a situation which has been found in the MHC of all teleosts mapped so far. The 300-kb contig comprises 24 MHC-related genes and is bounded by six non-MHC genes, which are thought to represent an evolutionary breakpoint withinthe region. Comparative analysis with both human and zebrafish MHC maps indicates two blocks of genes (KNSL2, ZNF297, DAXX, TAPBP, FLOTILLIN; and PSMB8, PSMB10, PSMB9, ABCB3, FABGL, BRD2, COL11A2, RXRB) which have remained linked over 400 million years and may represent an ancestral arrangement of the vertebrate MHC. Zebrafish and Fugu diverged diverged between 100-200 million years ago differences exist between these two fish species. The position and number of MHC class Ia genes is not conserved between species, there is an inversion of a block of nine genes centering on the PSMB cluster, and additional genes are present in zebrafish coding for a transport-associated protein and a beta proteasome sub-unit. The extent of these differenceshas implications for the extrapolation of fish model organism data to commercial aquaculture species. The data presented here represent the most extensive analysis of a fish MHC class Ia region described so far and clearly delimit the extent of this region in Fugu and, potentially, all teleosts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:01:07