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Titolo:
No evidence for BCL10 mutations in endometrial cancers with microsatelliteinstability
Autore:
Cohn, DE; Mutch, DG; Elbendary, A; Rader, JS; Herzog, TJ; Goodfellow, P;
Indirizzi:
Washington Univ, Sch Med, Dept Obstet & Gynecol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 t & Gynecol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Surg, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 , Dept Surg, St Louis, MO 63110 USA
Titolo Testata:
HUMAN MUTATION
fascicolo: 2, volume: 17, anno: 2001,
pagine: 117 - 121
SICI:
1059-7794(2001)17:2<117:NEFBMI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-MALIGNANT MESOTHELIOMA; CARCINOMA; ABSENCE; TARGET; REPAIR; MSH3; DNA;
Keywords:
BCL10; DHPLC; endometrial cancer; microsatellite instability; mononucleotide repeats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Cohn, DE Washington Univ, Sch Med, Dept Obstet & Gynecol, Box 8064,4911 Barnes HospPlaza, St Louis, MO 63110 USA Washington Univ Box 8064,4911 BarnesHosp Plaza St Louis MO USA 63110
Citazione:
D.E. Cohn et al., "No evidence for BCL10 mutations in endometrial cancers with microsatelliteinstability", HUM MUTAT, 17(2), 2001, pp. 117-121

Abstract

Previous reports have suggested that the mononucleotide repeats in BCL10 frequently are mutated in both hematologic malignancies and sold tumors. We set out to determine whether these repeats, like simple repeat sequences inother genes, are a target for mutation in endometrial cancers with defective DNA mismatch repair. Primary endometrial cancers (n = 42) and endometrial cancer cell lines (n=5) with microsatellite instability (MS1) were investigated. BCL10 exons 2 and 3 were amplified by PCR and evaluated for mutation using denaturing high-performance liquid chromatography (DHPLC) and single stand conformational variant (SSCV) analysis. Variants were directly sequenced. No BCL10 mutations were detected in exons 2 or 3 by DHPLC or SSCV. Apolymorphism in exon 3 (638G-->A) was seen in 4/42 (9.5%) MSI-positive endometrial cancers and 0/5 MSI-positive endometrial cancer cell lines. Thus, mutation in the mononucleotide repeat tracts of BCL10 is not a feature of endometrial cancers with defective DNA mismatch repair. Hum Mutat 17:117-121, 2001, (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:06:42