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Titolo:
Antenatal determination of fetal brain activity in response to an acousticstimulus using functional magnetic resonance imaging
Autore:
Moore, RJ; Vadeyar, S; Fulford, J; Tyler, DJ; Gribben, C; Baker, PN; James, D; Gowland, PA;
Indirizzi:
Univ Nottingham, Sch Phys & Astron, MRC, Nottingham NG7 2RD, England Univ Nottingham Nottingham England NG7 2RD , Nottingham NG7 2RD, England Univ Nottingham, Sch Human Dev, Nottingham NG7 2RD, England Univ Nottingham Nottingham England NG7 2RD , Nottingham NG7 2RD, England
Titolo Testata:
HUMAN BRAIN MAPPING
fascicolo: 2, volume: 12, anno: 2001,
pagine: 94 - 99
SICI:
1065-9471(200102)12:2<94:ADOFBA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MRI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Gowland, PA Univ Nottingham, Sch Phys & Astron, MRC, Nottingham NG7 2RD, England Univ Nottingham Nottingham England NG7 2RD NG7 2RD, England
Citazione:
R.J. Moore et al., "Antenatal determination of fetal brain activity in response to an acousticstimulus using functional magnetic resonance imaging", HUM BRAIN M, 12(2), 2001, pp. 94-99

Abstract

Functional magnetic resonance imaging (fMRI) is now a well-established technique for directly identifying adult brain activity. This study builds on earlier pilot work that showed that fMRI could provide direct evidence of fetal brain cortical activation in response to an auditory stimulus. The newwork presented here aims to assess the sensitivity: of this technique in alarger sample group. This article includes a specific discussion of the methodology required for fetal fMRI. Sixteen pregnant subjects were scanned between 37 and 41 weeks gestation, 12 had an auditory stimulus applied to the maternal abdomen (study group) and 4 had an auditory stimulus applied to the mother's ears (control group). Two of twelve (2/12) study-group patients experienced back pain so that the experiment was abandoned; 4/12 showed significant activation (P < 0.005) in one or both of the temporal lobes; 1/12 showed significant activation in the frontal lobe. A susceptibility artifact at the interface between the maternal bowel and the fetus affected 3/12data sets. No significant activation was found in 3/4 of the control cases, and 1/4 could not be analyzed due to a susceptibility artifact.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:58:58