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Titolo:
Safety issues in children and adolescents during growth hormone therapy - a review
Autore:
Clayton, PE; Cowell, CT;
Indirizzi:
Royal Alexandra Hosp Children, Robert Vines Growth Res Ctr, Sydney, NSW 2145, Australia Royal Alexandra Hosp Children Sydney NSW Australia 2145 W 2145, Australia Royal Manchester Childrens Hosp, Dept Child Hlth, Manchester M27 1HA, Lancs, England Royal Manchester Childrens Hosp Manchester Lancs England M27 1HA England
Titolo Testata:
GROWTH HORMONE & IGF RESEARCH
fascicolo: 6, volume: 10, anno: 2000,
pagine: 306 - 317
SICI:
1096-6374(200012)10:6<306:SIICAA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
BENIGN INTRACRANIAL HYPERTENSION; NATIONAL COOPERATIVE GROWTH; DEPENDENT DIABETES-MELLITUS; CAPITAL FEMORAL EPIPHYSIS; IDIOPATHIC SHORT STATURE; ULLRICH-TURNER-SYNDROME; CARBOHYDRATE-METABOLISM; FACTOR-I; TUMOR RECURRENCE; MELANOCYTIC NEVI;
Keywords:
growth hormone; adverse events; carbohydrate metabolism; slipped capital femoral epiphysis; malignancy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
97
Recensione:
Indirizzi per estratti:
Indirizzo: Cowell, CT Royal Alexandra Hosp Children, Robert Vines Growth Res Ctr, Locked Bag 4001, Sydney, NSW 2145, Australia Royal Alexandra Hosp Children Locked Bag 4001 Sydney NSW Australia 2145
Citazione:
P.E. Clayton e C.T. Cowell, "Safety issues in children and adolescents during growth hormone therapy - a review", GROWTH H I, 10(6), 2000, pp. 306-317

Abstract

The action of growth hormone (GH) via its receptor involves many organ systems and metabolic pathways. These diverse actions are reviewed in this paper in the context that they may represent unwanted side-effects of GH therapy for growth promotion. The monitoring of GH therapy in large multicentre international databases has demonstrated a low frequency of adverse events. Tumour recurrence or new malignancy are not increased, Headaches, especially in the first few months of therapy, require close evaluation as benign intracranial hypertension is found infrequently, especially in children withGH deficiency and chronic renal failure (CRF). Children at risk for slipped capital femoral epiphysis and scoliosis require close monitoring during therapy. Decreased insulin sensitivity that is dose-dependent is observed during GH therapy. Glucose homeostasis, however, is not affected, but a recent report of increased incidence of Type 2 diabetes mellitus in children undergoing GH therapy requires prospective surveillance. (C) 2000 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:53:00