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Titolo:
Analysis of genetic alterations in primary nasopharyngeal carcinoma by comparative genomic hybridization
Autore:
Fang, Y; Guan, XY; Guo, Y; Sham, JST; Deng, MQ; Liang, QW; Li, HM; Zhang, HG; Zhou, H; Trent, J;
Indirizzi:
NHGRI, Canc Genet Branch, NIH, Bethesda, MD 20892 USA NHGRI Bethesda MD USA 20892 anc Genet Branch, NIH, Bethesda, MD 20892 USA Sun Yat Sen Univ Med Sci, Ctr Canc, Guangzhou, Peoples R China Sun Yat SenUniv Med Sci Guangzhou Peoples R China hou, Peoples R China Univ Hong Kong, Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China
Titolo Testata:
GENES CHROMOSOMES & CANCER
fascicolo: 3, volume: 30, anno: 2001,
pagine: 254 - 260
SICI:
1045-2257(200103)30:3<254:AOGAIP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMOSOME ARM 16Q; HUMAN SARCOMAS; BREAST-CANCER; HETEROZYGOSITY; REGION; AMPLIFICATION; MDM2; IDENTIFICATION; ABERRATIONS; TUMORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Trent, J NHGRI, Canc Genet Branch, NIH, 49 Convent Dr MSC 4470,Rm 4A22, Bethesda, MD 20892 USA NHGRI 49 Convent Dr MSC 4470,Rm 4A22 Bethesda MD USA 20892 92 USA
Citazione:
Y. Fang et al., "Analysis of genetic alterations in primary nasopharyngeal carcinoma by comparative genomic hybridization", GENE CHROM, 30(3), 2001, pp. 254-260

Abstract

To identify genetic alterations associated with the development. and progression of human nasopharyngeal carcinoma (NPC), 57 tumors were analyzed by comparative genomic hybridization (CGH). In 47 cases, chromosomal imbalances were found. Several recurrent chromosomal abnormalities were identified in the present study. The most frequently detected chromosomal gains involved chromosome arms 12q (24 cases, 51%), 4q (17 cases, 36%), 3q (16 cases, 34%), 1q (15 cases, 32%), and 18q (15 cases, 32%). Common regions of gain involved 12q13-q15, 4q12-q21, and 3q21-q26. High-copy-number increases of chromosomal materials were detected in four chromosomal regions, 3q21-q26.2, 4p12-q21, 8p, and 12q14-q15. The most frequently detected loss of chromosomalmaterials involved chromosome arms 16q (26 cases, 55%), 14q (21 cases, 45%), 1p (20 cases, 43%), 3p (20 cases, 43%), 16p (19 cases. 40%), 1 Iq (17 cases, 36%), and 19p (16 cases, 34%). The most common regions of loss involved 14q24-qter, 1 pter-p36.1, 3p22-p21.3, 11q21-qter, and the distal region of 19p. Genomic alterations detected by CGH were compared and found to be largely consistent with those identified in banding analysis and loss of heterozygosity studies. However, several previously unrecognized recurrent alterations were also identified in the present study, including gain of 4q and18q, and loss of 16q, 14q, and 19p. In addition, gain of 1q, 8q, 18q, and loss of 9q showed a statistically significant association with advanced clinical stages (P < 0.05). Identification of recurrent sites of chromosomal gain and loss identify regions of the genome that may contain oncogenes or tumor suppressor genes, respectively, which may be involved in the tumorigenesis of NPC. Published 2001 Wiley-Liss, Inc(<dagger>).

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Documento generato il 30/05/20 alle ore 13:41:47