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Titolo:
Inhibition of Wnt activity induces heart formation from posterior mesoderm
Autore:
Marvin, MJ; Di Rocco, G; Gardiner, A; Bush, SM; Lassar, AB;
Indirizzi:
Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 em & Mol Pharmacol, Boston, MA 02115 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res Cambridge MA USA 02142 Cambridge, MA 02142 USA MIT, Cambridge, MA 02142 USA MIT Cambridge MA USA 02142MIT, Cambridge, MA 02142 USA
Titolo Testata:
GENES & DEVELOPMENT
fascicolo: 3, volume: 15, anno: 2001,
pagine: 316 - 327
SICI:
0890-9369(20010201)15:3<316:IOWAIH>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE MORPHOGENETIC PROTEIN-4; EARLY XENOPUS DEVELOPMENT; AVIAN CARDIAC MYOGENESIS; TINMAN-RELATED GENES; SPEMANN ORGANIZER; EMBRYONIC MESODERM; ANTERIOR ENDODERM; PRIMITIVE-STREAK; VENTRALIZING FACTOR; SECRETED PROTEINS;
Keywords:
crescent; Dkk-1; Wnt; heart induction; endoderm; erythropoiesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
81
Recensione:
Indirizzi per estratti:
Indirizzo: Lassar, AB Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 armacol, Boston, MA 02115 USA
Citazione:
M.J. Marvin et al., "Inhibition of Wnt activity induces heart formation from posterior mesoderm", GENE DEV, 15(3), 2001, pp. 316-327

Abstract

In the chick, heart mesoderm is induced by signals from the anterior endoderm. Although BMP-2 is expressed in the anterior endoderm, BMP activity is necessary but not sufficient for heart formation. Previous work from our lab has suggested that one or more additional factors from anterior endoderm are required. Crescent is a Frizzled-related protein that inhibits Wnt-8c and is expressed in anterior endoderm during gastrulation. At the same stages, expression of Wnt-3a and Wnt-8c is restricted to the primitive streak and posterior lateral plate, and is absent from the anterior region where crescent is expressed. Posterior lateral plate mesoderm normally forms blood, but coculture of this tissue with anterior endoderm or infection with RCAS-crescent induces formation of beating heart muscle and represses formation of blood. Dkk-1, a Wnt inhibitor of a different protein family, similarly induces heart-specific gene expression in posterior lateral plate mesoderm. Furthermore, we have found that ectopic Wnt signals can repress heart formation from anterior mesoderm in vitro and in vivo and that forced expressionof either Wnt-3a or Wnt-8c can promote development of primitive erythrocytes from the precardiac region. We conclude that inhibition of Wnt signalingpromotes heart formation in the anterior lateral mesoderm, whereas active Wnt signaling in the posterior lateral mesoderm promotes blood development. We propose a model in which two orthogonal gradients, one of Wnt activity along the anterior-posterior axis and the other of BMP signals along the dorsal-ventral axis, intersect in the heart-forming region to induce cardiogenesis in a region of high BMP and low Wnt activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:38:26