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Titolo:
Wnt antagonism initiates cardiogenesis in Xenopus laevis
Autore:
Schneider, VA; Mercola, M;
Indirizzi:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ed, Dept Cell Biol, Boston, MA 02115 USA
Titolo Testata:
GENES & DEVELOPMENT
fascicolo: 3, volume: 15, anno: 2001,
pagine: 304 - 315
SICI:
0890-9369(20010201)15:3<304:WAICIX>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE MORPHOGENETIC PROTEIN-4; AVIAN CARDIAC MYOGENESIS; CERBERUS-RELATED GENE; SPEMANN ORGANIZER; ANTERIOR ENDODERM; HEART DEVELOPMENT; NEURAL INDUCTION; SECRETED PROTEIN; EMBRYOS; EXPRESSION;
Keywords:
Dkk1; Wnt; heart induction; cardiogenesis; dorsal mesoderm;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Mercola, M Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ll Biol, Boston, MA 02115 USA
Citazione:
V.A. Schneider e M. Mercola, "Wnt antagonism initiates cardiogenesis in Xenopus laevis", GENE DEV, 15(3), 2001, pp. 304-315

Abstract

Heart induction in Xenopus occurs in paired regions of the dorsoanterior mesoderm in response to signals from the Spemann organizer and underlying dorsoanterior endoderm. These tissues together are sufficient to induce heartformation in noncardiogenic ventral marginal zone mesoderm. Similarly, in avians the underlying definitive endoderm induces cardiogenesis in precardiac mesoderm. Heart-inducing factors in amphibians are not known, and although certain BMPs and EGFs can mimic aspects of cardiogenesis in avians, neither can induce the full range of activities elicited by the inducing tissues. Here we report that the Wnt antagonists Dkk-1 and Crescent can induce heart formation in explants of ventral marginal zone mesoderm. Other Wnt antagonists, including the frizzled domain-containing proteins Frzb and Sz1, lacked this activity. Unlike Wnt antagonism, inhibition of BMP signaling did not promote cardiogenesis. Ectopic expression of GSK3 beta, which inhibits beta -catenin-mediated Wnt signaling, also induced cardiogenesis in ventralmesoderm. Analysis of Wnt proteins expressed during gastrulation revealed that Wnt3A and Wnt8, but not Wnt5A or Wnt11, inhibited endogenous heart induction. These results indicate that diffusion of Dkk-1 and Crescent from the organizer initiate cardiogenesis in adjacent mesoderm by establishing a zone of low Wnt3A and Wnt8 activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 00:05:01