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Titolo:
E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis
Autore:
Muller, H; Bracken, AP; Vernell, R; Moroni, MC; Christians, F; Grassilli, E; Prosperini, E; Vigo, E; Oliner, JD; Helin, K;
Indirizzi:
European Inst Oncol, Dept Expt Oncol, I-20141 Milan, Italy European Inst Oncol Milan Italy I-20141 Expt Oncol, I-20141 Milan, Italy Affymetrix Inc, Santa Clara, CA 95051 USA Affymetrix Inc Santa Clara CA USA 95051 ix Inc, Santa Clara, CA 95051 USA
Titolo Testata:
GENES & DEVELOPMENT
fascicolo: 3, volume: 15, anno: 2001,
pagine: 267 - 285
SICI:
0890-9369(20010201)15:3<267:ERTEOG>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR RECEPTORS; S-PHASE ENTRY; TRANSCRIPTION FACTORS; CELL-CYCLE; RETINOBLASTOMA PROTEIN; SIGNALING PATHWAYS; CHIMERIC MICE; INDUCTION; CDK2; PRB;
Keywords:
E2F; retinoblastoma; microarray; target gene bias;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Helin, K European Inst Oncol, Dept Expt Oncol, I-20141 Milan, Italy European Inst Oncol Milan Italy I-20141 l, I-20141 Milan, Italy
Citazione:
H. Muller et al., "E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis", GENE DEV, 15(3), 2001, pp. 267-285

Abstract

The retinoblastoma protein (pRB) and its two relatives, p107 and p130, regulate development and cell proliferation in part by inhibiting the activityof E2F-regulated promoters. We have used high-density oligonucleotide arrays to identify genes in which expression changed in response to activation of E2F1, E2F2, and E2F3. We show that the E2Fs control the expression of several genes that are involved in cell proliferation. We also show that the E2Fs regulate a number of genes involved in apoptosis, differentiation, anddevelopment. These results provide possible genetic explanations to the variety of phenotypes observed as a consequence of a deregulated pRB/E2F pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 06:10:06