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Titolo:
Ontogeny of neurohormonal peptides, serotonin, and nitric oxide synthase in the gastrointestinal neuroendocrine system of the axolotl (Ambystoma mexicanum): An immunohistochemical analysis
Autore:
Maake, C; Kaufmann, C; Reinecke, M;
Indirizzi:
Univ Zurich, Inst Anat, Div Neuroendocrinol, CH-8057 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8057 inol, CH-8057 Zurich, Switzerland
Titolo Testata:
GENERAL AND COMPARATIVE ENDOCRINOLOGY
fascicolo: 1, volume: 121, anno: 2001,
pagine: 74 - 83
SICI:
0016-6480(200101)121:1<74:OONPSA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOCRINE-CELLS; REGULATORY PEPTIDES; RANA-TEMPORARIA; XENOPUS-LAEVIS; NERVOUS-SYSTEM; SUBSTANCE-P; INTESTINE; NERVES; METAMORPHOSIS; LOCALIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Maake, C Univ Zurich, Inst Anat, Div Neuroendocrinol, CH-8057 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8057 8057 Zurich, Switzerland
Citazione:
C. Maake et al., "Ontogeny of neurohormonal peptides, serotonin, and nitric oxide synthase in the gastrointestinal neuroendocrine system of the axolotl (Ambystoma mexicanum): An immunohistochemical analysis", GEN C ENDOC, 121(1), 2001, pp. 74-83

Abstract

The ontogeny of the neurohormonal peptides vasoactive intestinal polypeptide (VIP), neurotensin (NT), substance P (SP), calcitonin gene-related peptide (CGRP), gastrin/cholecystokinin (GAS/CCK), and somatostatin (SOM) as well as serotonin (SER) and nitric oxide synthase (NOS) was investigated in the gastrointestinal tract of the urodele Ambystoma mexicanum, the axolotl, using immunohistochemical techniques. The first regulatory substances to appear were SP, SOM, and SER that could be immunohistochemically detected up from stage 1. At early stage 2, VIP immunoreactivity was observed infrequently in enteric nerve fibers. With the onset of external feeding at late stage 2, SP-immunoreactive (IR) and SER-IR endocrine cells and VIP-IR nerve fibers were present throughout the gastrointestinal tract. Furthermore, in thesmall intestine NT-IR and GAS/CCK-IR endocrine cells appeared. At stage 3,SER immunoreactivity was observed not only in endocrine cells but also in nerve fibers. CGRP-IR and SP-IR nerve fibers were detectable at stage 4 andstage 5, respectively. From stage 5 on, a minority of the CGRP immunoreactivity occurred in SP-IR nerve fibers. NOS immunoreactivity did not appear before stage 6 when it was found infrequently in nerve fibers. Thus, severalphases of development can be distinguished: (1) at the yolk sac stages only few regulatory substances are present. (2) At the onset of external feeding, all endocrine cell types investigated were readily detectable. Thus, the onset of external feeding seems to trigger the development of the gastrointestinal endocrine system. (3) The endocrine cells are first found in the proximal part of the gastrointestinal tract and later in higher numbers in the distal parts. (4) The dually distributed neurohormonal peptides and SERfirst appear in endocrine cells and later additionally in nerve fibers. Thus, the nerve fibers likely set up the fine regulation of gastrointestinal blood flow and motility. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 14:58:28