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Titolo:
Current approaches to the treatment of Candida albicans infections
Autore:
Burt, ET;
Indirizzi:
Des Moines Univ, Osteopath Med Ctr, Dept Biochem, Des Moines, IA 50312 USADes Moines Univ Des Moines IA USA 50312 Biochem, Des Moines, IA 50312 USA
Titolo Testata:
EXPERT OPINION ON THERAPEUTIC PATENTS
fascicolo: 2, volume: 11, anno: 2001,
pagine: 269 - 282
SICI:
1354-3776(200102)11:2<269:CATTTO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR MECHANISMS; AZOLE RESISTANCE; DRUG-RESISTANCE; RISK-FACTORS; DEMETHYLASE; ANTIFUNGALS; INHIBITION; MORTALITY; CORRELATE; AGENTS;
Keywords:
1-3 beta glucan synthase inhibitors; antifungals; azoles; Candida albicans; echinocandins; macrolides; polyenes;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
243
Recensione:
Indirizzi per estratti:
Indirizzo: Burt, ET Des Moines Univ, Osteopath Med Ctr, Dept Biochem, 3200 Grand Ave,Des Moines, IA 50312 USA Des Moines Univ 3200 Grand Ave Des Moines IA USA 50312 50312 USA
Citazione:
E.T. Burt, "Current approaches to the treatment of Candida albicans infections", EXPERT OP T, 11(2), 2001, pp. 269-282

Abstract

Candida albicans infections, once considered rare, are increasing in occurrence. This increase is due to the greater number of immunocompromised people undergoing cancer therapies or infected with HIV. Currently, candidal infections are typically treated wit either azole or polyene antifungal agents, although with the increased occurrence of C. albicans infections, there have also been reports of resistance to these agents. While the latest generation of azoles has remained effective, these drugs often have unpleasant side effects. The development of antifungal resistance and the side effectsof new generation azoles have crated a demand for new antifungal treatments. In response to this, over 200 patents have been filed in the past few years. these new agents include antifungal proteins and combinations of new and previously existing drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 21:31:27