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Titolo:
Quinoline antimalarials
Autore:
Egan, TJ;
Indirizzi:
Univ Cape Town, Dept Chem, ZA-7701 Rondebosch, South Africa Univ Cape Town Rondebosch South Africa ZA-7701 Rondebosch, South Africa
Titolo Testata:
EXPERT OPINION ON THERAPEUTIC PATENTS
fascicolo: 2, volume: 11, anno: 2001,
pagine: 185 - 209
SICI:
1354-3776(200102)11:2<185:QA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMODIAQUINE-INDUCED AGRANULOCYTOSIS; RESISTANT PLASMODIUM-FALCIPARUM; HUMAN MALARIA PARASITES; ACTIVITY IN-VITRO; CHLOROQUINE RESISTANCE; HEME POLYMERIZATION; DRUG-RESISTANCE; FERRIPROTOPORPHYRIN-IX; HEMATIN POLYMERIZATION; UNCOMPLICATED MALARIA;
Keywords:
aminoquinoline; antimalarial; chloroquine; malaria; mechanism; quinoline; resistance;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
157
Recensione:
Indirizzi per estratti:
Indirizzo: Egan, TJ Univ Cape Town, Dept Chem, ZA-7701 Rondebosch, South Africa Univ Cape Town Rondebosch South Africa ZA-7701 ch, South Africa
Citazione:
T.J. Egan, "Quinoline antimalarials", EXPERT OP T, 11(2), 2001, pp. 185-209

Abstract

Quinoline antimalarial patents and relevant scientific literature concerning their mechanism of action, mechanism of resistance and structure-function relationships are discussed in this review. The review provides a brief history of current antimalarial drugs and describes some salient features about their use, occurrence of drug resistance, their metabolism and known adverse effects. Recent advances in our understanding of the mechanism of action of 4-aminoquinolines, quinoline methanols and 8-aminoquinolines are discussed as is the current state of knowledge regarding the mechanism of drugresistance. New insights into structure-function relationships in 4-aminoquinolines, both with respect to activity and resistance, are emphasised. Finally, patents registered since 1997 are described and an expert opinion offered. The review emphasises advances made during the last four years.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:14:13