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Titolo:
Anti-anaerobic activity of antibacterial agents
Autore:
Bryskier, A;
Indirizzi:
Aventis Pharma, Infect Dis Grp, Clin Pharmacol, F-93235 Romainville, France Aventis Pharma Romainville France F-93235 l, F-93235 Romainville, France
Titolo Testata:
EXPERT OPINION ON INVESTIGATIONAL DRUGS
fascicolo: 2, volume: 10, anno: 2001,
pagine: 239 - 267
SICI:
1354-3784(200102)10:2<239:AAOAA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO ACTIVITY; BACTEROIDES-FRAGILIS GROUP; OXAZOLIDINONE ANTIMICROBIAL AGENTS; PENICILLIN-BINDING PROTEINS; SUSCEPTIBILITY PATTERNS; INVITRO ACTIVITY; BETA-LACTAMASES; PIPERACILLIN-TAZOBACTAM; TELITHROMYCIN HMR-3647; ORAL TROVAFLOXACIN;
Keywords:
anti-anaerobe drugs; carbapenems; cephamycins; chloramphenicol; clindamycin; fluoroquinolones; linezolid; metronidazole; streptogramins; telithromycin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
128
Recensione:
Indirizzi per estratti:
Indirizzo: Bryskier, A Aventis Pharma, Infect Dis Grp, Clin Pharmacol, 102 Route Noisy, F-93235 Romainville, France Aventis Pharma 102 Route Noisy Romainville France F-93235 nce
Citazione:
A. Bryskier, "Anti-anaerobic activity of antibacterial agents", EXPERT OP I, 10(2), 2001, pp. 239-267

Abstract

The first very effective bactericidal anti-anaerobic drug was metronidazole, introduced in clinical practice in the early 1980s. Sometimes penicillinG and chloramphenicol were used successfully in some anaerobic infections. However, this result was most likely due to Gram-positive anaerobic infections (e.g., Clostridium perfringens). Very rapidly, the anti-anaerobic armamentarium was extended with clindamycin, cefoxitin, imipenem and co-amoxyclav or piperacillin-tazobactam. The resistance rate to metronidazole and imipenem remains low but clindamycin has seen an importance decrease in bacterial susceptibility. New additional drugs could be very helpful to overcome resistance and adverse events. The novelties in this field are fluoroquinolones, which exhibit a good activity against Gram-positive cocci and anaerobes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:50:52